Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 6/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | ITK | Q08881 | 5/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | MELK | Q14680 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1026292 | 0.89 | SYK (0.42) | SYKALDH1A1EGFRBTKITK | |
| SCHEMBL1025879 | 0.86 | ALDH1A1 (0.43) | SYKALDH1A1EGFRBTKITK | |
| SCHEMBL1025753 | 0.80 | SYK (0.46) | SYKALDH1A1EGFRBTKITK | |
| SCHEMBL1025143 | 0.80 | BCL6 (0.40) | SYKALDH1A1EGFRBTKITK | |
| SCHEMBL13623055 | 0.79 | SYK (0.51) | SYKALDH1A1EGFRBTKITK | |
| SCHEMBL1023949 | 0.78 | ALDH1A1 (0.40) | ALDH1A1EGFRBTK | |
| SCHEMBL13623056 | 0.77 | SYK (0.48) | SYKALDH1A1AURKA | |
| SCHEMBL1025107 | 0.77 | MAOA (0.43) | — | |
| Hydrochloric Acid SCHEMBL1024932 | 0.77 | SYK (0.47) | SYKALDH1A1AURKA | |
| SCHEMBL1025701 | 0.76 | ALDH1A1 (0.49) | SYKALDH1A1EGFRBTKITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |