Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | BCL6 | P41182 | 1/20 | 0.38 |
| ▸ | CTSC | P53634 | 2/20 | 0.37 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 7/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
| ▸ | JAK3 | P52333 | 3/20 | 0.34 |
| ▸ | RHOA | P61586 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1025879 | 0.92 | ALDH1A1 (0.43) | ALDH1A1KDM4EGAABTKEGFR | |
| SCHEMBL1025143 | 0.87 | BCL6 (0.40) | ALDH1A1BCL6CTSCBTKEGFR | |
| SCHEMBL1026953 | 0.84 | GAA (0.47) | ALDH1A1GAABCL6BTK | |
| SCHEMBL1027670 | 0.84 | BCL6 (0.38) | ALDH1A1BCL6CTSCBTKEGFR | |
| SCHEMBL1026721 | 0.83 | JAK3 (0.42) | BCL6CTSCJAK3 | |
| SCHEMBL1026395 | 0.83 | BCL6 (0.40) | BCL6CTSCBTKEGFRJAK3 | |
| SCHEMBL4348221 | 0.83 | ALDH1A1 (0.46) | ALDH1A1KDM4EGAACTSCBTK | |
| SCHEMBL1023285 | 0.82 | ALK (0.40) | ALDH1A1BCL6BTK | |
| SCHEMBL1025086 | 0.81 | BCL6 (0.38) | ALDH1A1BCL6CTSCBTKEGFR | |
| SCHEMBL13623027 | 0.81 | SYK (0.44) | ALDH1A1KDM4EGAABCL6BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |