SCHEMBL10260950

SCHEMBL10260950

C[Si](C)(C)c1ccc(-c2cc(-c3ccc4ccccc4c3)c3ccc4ccc(-c5ccc6ccccc6c5)c5ccc2c3c45)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSTP1 P09211 1/20 0.39
CYP1A2 P05177 5/20 0.35
CYP2C9 P11712 3/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
ALDH1A1 P00352 3/20 0.35
CYP3A4 P08684 2/20 0.35
HPGD P15428 2/20 0.35
HSD17B10 Q99714 2/20 0.35
TSHR P16473 1/20 0.35
DHFR P00374 1/20 0.35
KDM4E B2RXH2 2/20 0.35
CYP11B1 P15538 3/20 0.35
CYP11B2 P19099 3/20 0.35
CYP2C19 P33261 2/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2B6 P20813 1/20 0.35
NPSR1 Q6W5P4 1/20 0.34
HDAC4 P56524 1/20 0.34
HDAC2 Q92769 1/20 0.34
HDAC8 Q9BY41 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10267621 1.00 GSTP1 (0.39) GSTP1CYP1A2CYP2C9SMN1; SMN2ALDH1A1
SCHEMBL10260057 1.00 GSTP1 (0.39) GSTP1CYP1A2CYP2C9SMN1; SMN2ALDH1A1
SCHEMBL13251051 0.94 GSTP1 (0.43) GSTP1CYP1A2CYP2C9SMN1; SMN2ALDH1A1
SCHEMBL13250954 0.94 GSTP1 (0.43) GSTP1CYP1A2CYP2C9SMN1; SMN2ALDH1A1
SCHEMBL13251176 0.90 ESR1 (0.42) GSTP1CYP1A2CYP2C9SMN1; SMN2ALDH1A1
SCHEMBL13251041 0.90 ESR1 (0.42) GSTP1CYP1A2CYP2C9SMN1; SMN2ALDH1A1
SCHEMBL10267570 0.88 ENPP1 (0.44) CYP1A2CYP2C9SMN1; SMN2ALDH1A1HPGD
SCHEMBL10260670 0.86 CYP1A2 (0.40) CYP1A2ALDH1A1HPGDHSD17B10TSHR
SCHEMBL15945809 0.86 GSTP1 (0.41) GSTP1CYP1A2CYP2C9SMN1; SMN2ALDH1A1
SCHEMBL3689582 0.85 GSTP1 (0.46) GSTP1CYP1A2CYP2C9SMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10950803-B2 Compounds and uses in devices UNIVERSAL DISPLAY CORPORATION (US) 2021-03-16 US disclosed
US-20190319194-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2019-10-17 US disclosed
US-10381569-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2019-08-13 US disclosed
US-20160149139-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2016-05-26 US disclosed
US-20160149139-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2016-05-26 US disclosed
US-20160104847-A1 NOVEL COMPOUNDS AND USES IN DEVICES UNIVERSAL DISPLAY CORPORATION 2016-04-14 US disclosed
US-20160104847-A1 NOVEL COMPOUNDS AND USES IN DEVICES UNIVERSAL DISPLAY CORPORATION 2016-04-14 US disclosed
US-20120168733-A1 PYRENE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT USING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2012-07-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120168733-A1 PYRENE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT USING THE SAME ESR2, AHR, AR GSTP1 1477/4885CYP1A2 115/4885CYP2C9 677/4885
US-20160104847-A1 NOVEL COMPOUNDS AND USES IN DEVICES TERT, UACA, TXN GSTP1 2496/4885CYP1A2 3435/4885CYP2C9 2193/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.