Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.38 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10200427 | 0.86 | KDR (0.53) | BRAFHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL545646 | 0.76 | RAF1 (0.56) | METBRAFHDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL545435 | 0.75 | RAF1 (0.55) | METBRAFHDAC3HDAC4HDAC1 | |
| SCHEMBL5424081 | 0.74 | KDR (0.60) | BRAFKDR | |
| SCHEMBL10262734 | 0.74 | P2RX3 (0.44) | BRAFHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL545301 | 0.73 | KDR (0.59) | BRAFKDR | |
| SCHEMBL545714 | 0.73 | KDM4E (0.52) | BRAFHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10263998 | 0.72 | KDR (0.55) | BRAFKDR | |
| SCHEMBL10262752 | 0.71 | KMT2A (0.39) | BRAFHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10262556 | 0.70 | AXL (0.41) | METBRAFHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |