Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1025111 | 0.88 | HTR3E (0.49) | HRH3MAPTTTRALDH1A1KDM4E | |
| Acetic Acid SCHEMBL1026461 | 0.83 | FFAR1 (0.49) | FFAR1HRH3MAPTTTRGRM1 | |
| SCHEMBL1026902 | 0.82 | HRH3 (0.41) | HRH3MAPTSMN1; SMN2ALDH1A1ACACB | |
| SCHEMBL1024083 | 0.78 | KDM4E (0.45) | MAPTSMN1; SMN2ALDH1A1KDM4ECYP2C9 | |
| SCHEMBL1025550 | 0.78 | FFAR1 (0.44) | FFAR1HRH3TTRGRM1 | |
| SCHEMBL1026519 | 0.77 | MAPT (0.40) | HRH3MAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL1026171 | 0.77 | HRH3 (0.46) | HRH3MAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL1027045 | 0.76 | MAPT (0.43) | HRH3MAPTSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL1025769 | 0.75 | SCD (0.41) | HRH3MAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL1025527 | 0.75 | MAPT (0.38) | MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009132202-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-10-29 | — | — | WO | disclosed |