Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1027045 | 0.88 | MAPT (0.43) | ALDH1A1HCRTR2MAPTSMN1; SMN2SCD | |
| Acetic Acid SCHEMBL1024079 | 0.81 | KDM4E (0.51) | KDM4ECYP2C19GPR119ALDH1A1HPGD | |
| SCHEMBL1026869 | 0.81 | KDM4E (0.53) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL1026902 | 0.80 | HRH3 (0.41) | GPR119ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL1026519 | 0.80 | MAPT (0.40) | KDM4ECYP2C19ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL1026171 | 0.79 | HRH3 (0.46) | KDM4EALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL1026463 | 0.78 | FFAR1 (0.45) | KDM4ECYP2C19ALDH1A1HPGDMAPT | |
| SCHEMBL1025527 | 0.78 | MAPT (0.38) | GPR119MAPTSMN1; SMN2 | |
| SCHEMBL1025111 | 0.78 | HTR3E (0.49) | KDM4ECYP2C19ALDH1A1HPGDMAPT | |
| SCHEMBL1027149 | 0.77 | HRH3 (0.51) | ALDH1A1MAPTSMN1; SMN2SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009132202-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-10-29 | — | — | WO | disclosed |