Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.38 |
| ▸ | GPR6 | P46095 | 7/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL1025524 | 0.84 | CYP46A1 (0.41) | CYP46A1GPR6ROCK2PRKG1CYP19A1 | |
| SCHEMBL1027705 | 0.78 | CYP46A1 (0.39) | CYP46A1GPR6ROCK2PRKG1GPR119 | |
| SCHEMBL1027045 | 0.78 | MAPT (0.43) | MAPTSMN1; SMN2AOC3 | |
| SCHEMBL1024083 | 0.78 | KDM4E (0.45) | MAPTSMN1; SMN2GPR119 | |
| SCHEMBL1026519 | 0.77 | MAPT (0.40) | MAPTSMN1; SMN2 | |
| SCHEMBL1026463 | 0.75 | FFAR1 (0.45) | MAPTSMN1; SMN2 | |
| SCHEMBL1024811 | 0.75 | THRB (0.41) | MAPTGPR6GRM5 | |
| SCHEMBL1026902 | 0.74 | HRH3 (0.41) | MAPTSMN1; SMN2GPR119 | |
| SCHEMBL1026171 | 0.74 | HRH3 (0.46) | MAPTSMN1; SMN2 | |
| SCHEMBL1025111 | 0.72 | HTR3E (0.49) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009132202-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-10-29 | — | — | WO | disclosed |