Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 8/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | KDM6B | O15054 | 3/20 | 0.55 |
| ▸ | KDM5C | P41229 | 3/20 | 0.55 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.55 |
| ▸ | KDM3A | Q9Y4C1 | 3/20 | 0.55 |
| ▸ | KDM4A | O75164 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM5A | P29375 | 2/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.46 |
| ▸ | TET3 | O43151 | 1/20 | 0.46 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ASPH | Q12797 | 1/20 | 0.46 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.46 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.46 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.46 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.46 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.46 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6398480 | 0.86 | KDM4C (0.49) | KDM4CKDM4EKDM6BKDM5CKDM2A | |
| SCHEMBL11340185 | 0.80 | KDM4E (0.55) | KDM4CKDM4EKDM6BKDM5CKDM2A | |
| SCHEMBL2635635 | 0.79 | HPGD (0.49) | KDM4CKDM4EKDM6BKDM5CKDM2A | |
| Hydrochloric Acid SCHEMBL15973575 | 0.78 | KDM4E (0.53) | KDM4CKDM4EKDM6BKDM5CKDM2A | |
| SCHEMBL231127 | 0.77 | CYP2D6 (0.57) | KDM4EALDH1A1TSHRLMNAP4HTM | |
| SCHEMBL4852129 | 0.76 | KDM4C (0.47) | KDM4CKDM4EKDM6BKDM5CKDM2A | |
| Methane SCHEMBL28533749 | 0.75 | CYP2D6 (0.55) | KDM4EALDH1A1TSHRLMNAP4HTM | |
| Hydrochloric Acid SCHEMBL6775520 | 0.75 | CYP2D6 (0.55) | KDM4EALDH1A1TSHRLMNAP4HTM | |
| SCHEMBL24473745 | 0.74 | KDM5B (0.50) | KDM4CKDM4EKDM6BKDM5CKDM2A | |
| SCHEMBL2811985 | 0.74 | PROKR1 (0.49) | KDM4CKDM4EKDM6BKDM5CKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138189-B2 | Substituted benzene compounds as modulators of the glucocorticoid receptor | HOFFMAN-LA ROCHE INC. (US) | 2012-03-20 | — | — | US | disclosed |
| US-20100249139-A1 | 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | HOFFMANN-LA ROCHE, INC. | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249139-A1 | 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | NR3C1, NR3C2, CRHR1 | KDM4C 3615/4885KDM4E 1499/4885KDM6B 4518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.