Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 3/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.58 |
| ▸ | CDK2 | P24941 | 3/20 | 0.58 |
| ▸ | FLT3 | P36888 | 3/20 | 0.58 |
| ▸ | CDC7 | O00311 | 2/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.58 |
| ▸ | PAK4 | O96013 | 2/20 | 0.58 |
| ▸ | CLK2 | P49760 | 2/20 | 0.58 |
| ▸ | GSK3A | P49840 | 2/20 | 0.58 |
| ▸ | PRKX | P51817 | 2/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.58 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.58 |
| ▸ | MELK | Q14680 | 2/20 | 0.58 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.58 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | PRKACA | P17612 | 1/20 | 0.58 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2527438 | 0.86 | FLT3 (0.62) | CDK7ROCK2CDK2FLT3CDC7 | |
| SCHEMBL761113 | 0.83 | JAK2 (0.62) | CDK7ROCK2FLT3CDC7DAPK3 | |
| SCHEMBL760581 | 0.82 | ULK1 (0.53) | CDK7ROCK2CDK2FLT3CDC7 | |
| SCHEMBL4438696 | 0.81 | CDK7 (0.60) | CDK7ROCK2CDK2FLT3CDC7 | |
| SCHEMBL10269232 | 0.80 | ROCK1 (0.57) | CDK7ROCK2CDK2FLT3CDC7 | |
| SCHEMBL1179465 | 0.79 | CDK7 (0.62) | CDK7ROCK2CDK2FLT3CDC7 | |
| SCHEMBL4784161 | 0.76 | HDAC6 (0.58) | CDK7ROCK2CDK2FLT3CDC7 | |
| SCHEMBL1335092 | 0.76 | NTRK1 (0.61) | CDK7FLT3CDC7DAPK3PAK4 | |
| SCHEMBL627302 | 0.75 | GSK3B (0.60) | CDK2DAPK3CLK2GSK3ACDK5 | |
| SCHEMBL1230073 | 0.75 | FADS1 (0.56) | CDK7ROCK2CDK2FLT3CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053345-A1 | Indazole Compounds | ABBOTT LABORATORIES (US) | 2012-03-01 | — | — | US | disclosed |
| US-8008481-B2 | Indazole compounds | ABBVIE INC. | 2011-08-30 | — | — | US | disclosed |
| US-20070282101-A1 | Indazole compounds | ABBVIE INC. | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070282101-A1 | Indazole compounds | CYP3A43, CYP3A7, UGT1A1 | CDK7 693/4885ROCK2 3219/4885CDK2 790/4885 |
| US-20120053345-A1 | Indazole Compounds | CYP3A43, CYP3A7, UGT1A1 | CDK7 693/4885ROCK2 3219/4885CDK2 790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.