Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 10/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.54 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.54 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28737629 | 0.80 | PIK3CD (0.41) | FGFR1PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL28104327 | 0.80 | FGFR1 (0.65) | FGFR1PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL7089345 | 0.79 | MAP3K11 (0.56) | FGFR1PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL14404415 | 0.76 | FGFR1 (0.68) | FGFR1PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL31174412 | 0.76 | CYP2A6 (0.68) | PIK3CAPIK3CDPIK3CBPIK3CGFYN | |
| SCHEMBL3754419 | 0.76 | CYP2A6 (0.68) | PIK3CAPIK3CDPIK3CBPIK3CGFYN | |
| SCHEMBL13115655 | 0.74 | FGFR1 (0.71) | FGFR1PIK3CDPIK3CBFGFR2FGFR3 | |
| SCHEMBL5252959 | 0.73 | FGFR1 (0.51) | FGFR1PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL7328650 | 0.73 | MAP3K11 (0.70) | PIK3CAPIK3CDPIK3CBPIK3CGDYRK3 | |
| SCHEMBL7273777 | 0.72 | LOXL2 (0.61) | PIK3CAPIK3CDPIK3CBPIK3CGMKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053345-A1 | Indazole Compounds | ABBOTT LABORATORIES (US) | 2012-03-01 | — | — | US | disclosed |
| US-8008481-B2 | Indazole compounds | ABBVIE INC. | 2011-08-30 | — | — | US | disclosed |
| US-8008481-B2 | Indazole compounds | ABBVIE INC. | 2011-08-30 | — | — | US | disclosed |
| US-20070282101-A1 | Indazole compounds | ABBVIE INC. | 2007-12-06 | — | — | US | disclosed |
| US-20070282101-A1 | Indazole compounds | ABBVIE INC. | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070282101-A1 | Indazole compounds | CYP3A43, CYP3A7, UGT1A1 | FGFR1 524/4885PIK3CA 979/4885PIK3CD 1488/4885 |
| US-20120053345-A1 | Indazole Compounds | CYP3A43, CYP3A7, UGT1A1 | FGFR1 524/4885PIK3CA 979/4885PIK3CD 1488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.