Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 2/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | INSR | P06213 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | LYN | P07948 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10270746 | 0.89 | MAP4K2 (0.51) | MAP4K2SYKALDH1A1AURKAJAK2 | |
| SCHEMBL12680514 | 0.86 | GSK3B (0.39) | MAP4K2SLK | |
| SCHEMBL10270290 | 0.85 | MAP4K2 (0.40) | MAP4K2SYKKDM4EALDH1A1MAPT | |
| SCHEMBL14079524 | 0.83 | MAPK9 (0.34) | MAP4K2NPC1RAB9AMAP4K4 | |
| SCHEMBL10270541 | 0.82 | MAP4K2 (0.38) | MAP4K2SYKALDH1A1AURKAJAK2 | |
| SCHEMBL10270304 | 0.80 | SYK (0.36) | MAP4K2SYKAURKAJAK2MAP4K4 | |
| SCHEMBL10270004 | 0.80 | PRKAB2 (0.35) | MAP4K2NPC1RAB9ABTK | |
| SCHEMBL10270292 | 0.80 | SYK (0.39) | MAP4K2SYKAURKAJAK2MAP4K4 | |
| SCHEMBL10269941 | 0.79 | METAP1 (0.35) | SMN1; SMN2NPC1MAPTRAB9ABTK | |
| SCHEMBL10270297 | 0.78 | MAP4K4 (0.36) | MAP4K2SYKNPC1AURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137188-B1 | SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES | Bayer Pharma AG (DE) | 2012-06-06 | — | — | EP | disclosed |
| WO-2008113469-A2 | SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-09-25 | — | — | WO | disclosed |