Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | LYN | P07948 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10270540 | 0.89 | MAP4K2 (0.40) | MAP4K2ALDH1A1LYNSRCBTK | |
| SCHEMBL10270541 | 0.88 | MAP4K2 (0.38) | MAP4K2CYP1A2CLK4LIMK1CYP3A4 | |
| SCHEMBL12680510 | 0.86 | MAP4K2 (0.47) | MAP4K2CYP1A2CLK4FLT1CDK8 | |
| SCHEMBL10270290 | 0.83 | MAP4K2 (0.40) | MAP4K2CLK4ROCK1ALDH1A1HSD17B10 | |
| SCHEMBL10270292 | 0.82 | SYK (0.39) | MAP4K2CYP1A2CLK4ROCK1MAPK1 | |
| SCHEMBL14079524 | 0.82 | MAPK9 (0.34) | MAP4K2CYP1A2CLK4LIMK1CYP3A4 | |
| SCHEMBL10270304 | 0.81 | SYK (0.36) | MAP4K2CLK4ROCK1MAPK1HRH4 | |
| SCHEMBL10269928 | 0.80 | HRH4 (0.48) | MAP4K2CLK4ROCK1MAPK1HRH4 | |
| SCHEMBL10270160 | 0.79 | MAP4K2 (0.54) | MAP4K2CYP1A2CLK4ROCK1CYP3A4 | |
| SCHEMBL10270744 | 0.79 | MAP4K2 (0.45) | MAP4K2CLK4ROCK1CYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137188-B1 | SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES | Bayer Pharma AG (DE) | 2012-06-06 | — | — | EP | disclosed |
| WO-2008113469-A2 | SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-09-25 | — | — | WO | disclosed |