SCHEMBL10270541

SCHEMBL10270541

Nc1ccc(NCCNc2nc(-c3ccccc3Cl)cc3nccn23)nc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAP4K2 Q12851 2/20 0.38
MAPK14 Q16539 6/20 0.36
HSP90AA1 P07900 1/20 0.34
HSP90AB1 P08238 1/20 0.34
CYP1A2 P05177 3/20 0.34
ALOX15 P16050 2/20 0.34
TSHR P16473 2/20 0.34
CYP2C19 P33261 2/20 0.34
ALDH1A1 P00352 1/20 0.34
HSD17B10 Q99714 1/20 0.34
CYP3A4 P08684 2/20 0.33
CHRNA7 P36544 1/20 0.33
ADORA2A P29274 1/20 0.33
ADORA1 P30542 1/20 0.33
CNR2 P34972 1/20 0.33
HRH4 Q9H3N8 2/20 0.32
CDK2 P24941 1/20 0.32
CYP2D6 P10635 1/20 0.32
MAPK1 P28482 1/20 0.32
CLK4 Q9HAZ1 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10270746 0.88 MAP4K2 (0.51) MAP4K2CYP1A2ALOX15TSHRCYP2C19
SCHEMBL12680518 0.86 GSK3B (0.41) MAP4K2MAPK14CYP1A2ALOX15TSHR
SCHEMBL10269941 0.85 METAP1 (0.35) CYP1A2CYP2C19CYP3A4CYP2D6BTK
SCHEMBL10270304 0.85 SYK (0.36) MAP4K2HRH4CDK2MAPK1CLK4
SCHEMBL10269928 0.83 HRH4 (0.48) MAP4K2HRH4CDK2MAPK1CLK4
SCHEMBL10270292 0.82 SYK (0.39) MAP4K2CYP1A2HRH4CDK2MAPK1
SCHEMBL10270540 0.82 MAP4K2 (0.40) MAP4K2ALDH1A1AURKAJAK2MAP4K4
SCHEMBL14079524 0.82 MAPK9 (0.34) MAP4K2MAPK14CYP1A2CYP3A4ADORA2A
SCHEMBL10270290 0.80 MAP4K2 (0.40) MAP4K2ALDH1A1HSD17B10HRH4CDK2
SCHEMBL10270004 0.79 PRKAB2 (0.35) MAP4K2CYP1A2TSHRBTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2137188-B1 SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES Bayer Pharma AG (DE) 2012-06-06 EP disclosed
WO-2008113469-A2 SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-09-25 WO disclosed