Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | SPR | P35270 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10270829 | 1.00 | HSD11B1 (0.38) | HSD11B1ADRA1AOPRM1OPRL1PRKCA | |
| SCHEMBL15199128 | 0.83 | HSD11B1 (0.39) | HSD11B1ADRA1AOPRM1OPRL1PRKCA | |
| SCHEMBL15199130 | 0.83 | HSD11B1 (0.39) | HSD11B1ADRA1AOPRM1OPRL1PRKCA | |
| SCHEMBL572676 | 0.81 | HSD11B1 (0.40) | HSD11B1ADRA1AOPRM1OPRL1PRKCA | |
| SCHEMBL8242924 | 0.81 | HSD11B1 (0.40) | HSD11B1ADRA1AOPRM1OPRL1PRKCA | |
| SCHEMBL572545 | 0.80 | HSD11B1 (0.37) | HSD11B1ADRA1AOPRM1OPRL1PRKCA | |
| SCHEMBL7228658 | 0.79 | OPRL1 (0.42) | HSD11B1ADRA1AOPRM1OPRL1SLC6A2 | |
| SCHEMBL7157630 | 0.77 | HSD11B1 (0.43) | HSD11B1ADRA1AOPRM1OPRL1PRKCA | |
| SCHEMBL30419444 | 0.77 | HSD11B1 (0.43) | HSD11B1ADRA1AOPRM1OPRL1PRKCA | |
| SCHEMBL24434639 | 0.76 | OPRM1 (0.35) | OPRM1OPRL1SLC6A2SLC6A4CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012018668-A1 | BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | AMGEN INC. (US) | 2012-02-09 | — | — | WO | disclosed |