Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.33 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17132555 | 1.00 | HSD17B10 (0.50) | HSD17B10SMN1; SMN2ROCK2ROCK1LMNA | |
| SCHEMBL16477306 | 0.83 | HSD17B10 (0.46) | HSD17B10SMN1; SMN2ROCK2ROCK1LMNA | |
| SCHEMBL10270138 | 0.83 | HSD17B10 (0.46) | HSD17B10SMN1; SMN2ROCK2ROCK1LMNA | |
| SCHEMBL14654910 | 0.81 | SMN1; SMN2 (0.55) | HSD17B10SMN1; SMN2KMT2ANAMPTPOLB | |
| SCHEMBL17133510 | 0.81 | SMN1; SMN2 (0.55) | HSD17B10SMN1; SMN2KMT2ANAMPTPOLB | |
| SCHEMBL15200319 | 0.81 | SMN1; SMN2 (0.55) | HSD17B10SMN1; SMN2KMT2ANAMPTPOLB | |
| SCHEMBL17132547 | 0.79 | LMNA (0.49) | HSD17B10SMN1; SMN2ROCK2ROCK1LMNA | |
| SCHEMBL24474315 | 0.77 | ROCK2 (0.46) | HSD17B10SMN1; SMN2ROCK2ROCK1LMNA | |
| SCHEMBL10270129 | 0.77 | ROCK2 (0.46) | HSD17B10ROCK2ROCK1LMNATDP1 | |
| SCHEMBL24474359 | 0.77 | ROCK2 (0.46) | HSD17B10ROCK2ROCK1LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012018668-A1 | BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | AMGEN INC. (US) | 2012-02-09 | — | — | WO | disclosed |