Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 1.00 |
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20773543 | 0.86 | TRPM8 (0.76) | TRPM8RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL20773828 | 0.85 | TRPM8 (0.74) | TRPM8RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL22074335 | 0.85 | TRPM8 (0.74) | TRPM8RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5992625 | 0.83 | TRPM8 (0.70) | TRPM8RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL10271042 | 0.83 | TRPM8 (0.71) | TRPM8RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL22074360 | 0.81 | TRPM8 (0.68) | TRPM8RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL5995153 | 0.80 | TRPM8 (0.67) | TRPM8RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL2718698 | 0.80 | TRPM8 (0.67) | TRPM8RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL5992993 | 0.80 | TRPM8 (0.71) | TRPM8RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL5992495 | 0.79 | TRPM8 (0.65) | TRPM8RAB9ANPC1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3675809-B1 | USE OF PHYSIOLOGICAL COOLING INGREDIENTS AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | BASF SE (DE) | 2023-09-27 | — | — | EP | disclosed |
| WO-2022207944-A9 | NOVEL MIXTURES AND USES OF (2E)-3-(1,3-BENZODIOXOL-5-YL)-N-PHENYL-N-(TETRAHYDRO-3-FURANYL)-2-PROPENAMIDE | SYMRISE AG (DE) | 2022-12-15 | — | — | WO | disclosed |
| US-11044931-B2 | Low molecular weight modulators of the cold menthol receptor TRPM8 and use thereof | BASF SE (DE) | 2021-06-29 | — | — | US | disclosed |
| EP-2758041-B1 | LOW-MOLECULAR MODULATORS OF THE COLD-MENTHOL RECEPTOR TRPM8 AND USE OF SAME | BASF SE (DE) | 2021-01-13 | — | — | EP | disclosed |
| EP-3698779-A1 | DETECTION AND USE OF LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 | BASF SE (DE) | 2020-08-26 | — | — | EP | disclosed |
| EP-3115045-B1 | DETECTION AND USE OF LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 | BASF SE (DE) | 2020-08-12 | — | — | EP | disclosed |
| EP-3103447-B1 | DETECTION AND USE OF LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 | BASF SE (DE) | 2020-08-05 | — | — | EP | disclosed |
| US-20200190052-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND COMPOSITIONS COMPRISING SUCH ACTIVE INGREDIENTS | BASF SE (DE) | 2020-06-18 | — | — | US | disclosed |
| EP-2501761-B1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2020-06-17 | — | — | EP | disclosed |
| EP-3663366-A2 | USE OF PHYSIOLOGICAL COOLING INGREDIENTS AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | Symrise AG (DE) | 2020-06-10 | — | — | EP | disclosed |
| US-8710096-B2 | Detection and use of low molecular-weight modulators of the cold-menthol receptor TRPM8 | BASF SE (DE) | 2014-04-29 | — | — | US | disclosed |
| US-8710096-B2 | Detection and use of low molecular-weight modulators of the cold-menthol receptor TRPM8 | BASF SE (DE) | 2014-04-29 | — | — | US | disclosed |
| WO-2013041621-A1 | LOW MOLECULAR WEIGHT MODULATORS OF THE COLD-MENTHOL RECEPTOR TRPM8 AND USE THEREOF | BASF SE (DE) | 2013-03-28 | — | — | WO | disclosed |
| US-20120263659-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | BASF SE (DE) | 2012-10-18 | — | — | US | disclosed |
| US-20120263659-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | BASF SE (DE) | 2012-10-18 | — | — | US | disclosed |
| WO-2011061330-A9 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2012-01-05 | — | — | WO | disclosed |
| US-20110145970-A1 | DETECTION AND USE OF LOW MOLECULAR-WEIGHT MODULATORS OF THE COLD-MENTHOL RECEPTOR TRPM8 | BASF SE (DE) | 2011-06-23 | — | — | US | disclosed |
| US-20110145970-A1 | DETECTION AND USE OF LOW MOLECULAR-WEIGHT MODULATORS OF THE COLD-MENTHOL RECEPTOR TRPM8 | BASF SE (DE) | 2011-06-23 | — | — | US | disclosed |
| WO-2011061330-A2 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2011-05-26 | — | — | WO | disclosed |
| WO-2010026094-A1 | DETECTION AND USE OF LOW MOLECULAR-WEIGHT MODULATORS OF THE COLD-MENTHOL RECEPTOR TRPM8 | BASF SE (DE) | 2010-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11044931-B2 | Low molecular weight modulators of the cold menthol receptor TRPM8 and use thereof | TRPM8, TRPM7, TRPM2 | TRPM8 1/4885RAB9A 2487/4885NPC1 2315/4885 |
| US-20110145970-A1 | DETECTION AND USE OF LOW MOLECULAR-WEIGHT MODULATORS OF THE COLD-MENTHOL RECEPTOR TRPM8 | TRPM8, TRPM2, TRPM7 | TRPM8 1/4885RAB9A 3624/4885NPC1 2241/4885 |
| US-20120263659-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | TRPM8, TRPM7, TRPM2 | TRPM8 1/4885RAB9A 2143/4885NPC1 1058/4885 |
| US-20200190052-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND COMPOSITIONS COMPRISING SUCH ACTIVE INGREDIENTS | TRPM8, TRPM7, TRPM5 | TRPM8 1/4885RAB9A 3290/4885NPC1 708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.