Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 9/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | SNCA | P37840 | 1/20 | 0.52 |
| ▸ | F3 | P13726 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.51 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18575785 | 0.91 | TRPM8 (0.84) | TRPM8LMNABCHECYP3A4NFKB1 | |
| SCHEMBL18536909 | 0.91 | TRPM8 (0.83) | TRPM8LMNABCHECYP3A4NFKB1 | |
| SCHEMBL29779967 | 0.87 | TRPM8 (0.77) | TRPM8LMNABCHECYP3A4NFKB1 | |
| SCHEMBL20777273 | 0.87 | TRPM8 (0.77) | TRPM8LMNABCHECYP3A4NFKB1 | |
| SCHEMBL10270952 | 0.86 | TRPM8 (1.00) | TRPM8LMNABCHESNCAMEN1 | |
| SCHEMBL22100701 | 0.86 | TRPM8 (0.75) | TRPM8LMNABCHECYP3A4NFKB1 | |
| SCHEMBL4129308 | 0.85 | TRPM8 (0.74) | TRPM8LMNABCHECYP3A4NFKB1 | |
| SCHEMBL4129312 | 0.85 | TRPM8 (0.74) | TRPM8LMNABCHECYP3A4NFKB1 | |
| SCHEMBL18536980 | 0.85 | TRPM8 (0.74) | TRPM8CYP3A4NPC1RAB9AALDH1A1 | |
| SCHEMBL30532218 | 0.82 | TRPM8 (1.00) | TRPM8LMNABCHECYP3A4NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10829451-B2 | Compounds for optically active devices | MERCK PATENT GMBH (DE) | 2020-11-10 | — | — | US | disclosed |
| EP-2501761-B1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2020-06-17 | — | — | EP | disclosed |
| EP-3663366-A2 | USE OF PHYSIOLOGICAL COOLING INGREDIENTS AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | Symrise AG (DE) | 2020-06-10 | — | — | EP | disclosed |
| US-20180162817-A1 | COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | MERCK PATENT GMBH (DE) | 2018-06-14 | — | — | US | disclosed |
| US-20180093997-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2018-04-05 | — | — | US | disclosed |
| US-20180093997-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2018-04-05 | — | — | US | disclosed |
| US-9718839-B2 | Use of physiological cooling active ingredients, and agents containing such active ingredients | SYMRISE AG (DE) | 2017-08-01 | — | — | US | disclosed |
| US-9718839-B2 | Use of physiological cooling active ingredients, and agents containing such active ingredients | SYMRISE AG (DE) | 2017-08-01 | — | — | US | disclosed |
| WO-2017032443-A1 | COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | MERCK PATENT GMBH (DE) | 2017-03-02 | — | — | WO | disclosed |
| EP-3133067-A1 | COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | Merck Patent GmbH (DE) | 2017-02-22 | — | — | EP | disclosed |
| US-20150086491-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2015-03-26 | — | — | US | disclosed |
| US-20150086491-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2015-03-26 | — | — | US | disclosed |
| US-8927605-B2 | Use of physiological cooling active ingredients, and agents containing such active ingredients | SYMRISE AG (DE) | 2015-01-06 | — | — | US | disclosed |
| US-8927605-B2 | Use of physiological cooling active ingredients, and agents containing such active ingredients | SYMRISE AG (DE) | 2015-01-06 | — | — | US | disclosed |
| US-20120263659-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | BASF SE (DE) | 2012-10-18 | — | — | US | disclosed |
| US-20120263659-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | BASF SE (DE) | 2012-10-18 | — | — | US | disclosed |
| WO-2011061330-A9 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2012-01-05 | — | — | WO | disclosed |
| WO-2011061330-A2 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2011-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162817-A1 | COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | PDE6C, ALDH1A2, PDE6A | TRPM8 52/4885LMNA 4267/4885BCHE 584/4885 |
| US-10829451-B2 | Compounds for optically active devices | PDE6C, ALDH1A2, PDE6A | TRPM8 52/4885LMNA 4267/4885BCHE 584/4885 |
| US-20150086491-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | TRPM8, TRPM7, TRPM2 | TRPM8 1/4885LMNA 1782/4885BCHE 3695/4885 |
| US-20180093997-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | TRPM8, TRPM7, TRPM2 | TRPM8 1/4885LMNA 1782/4885BCHE 3695/4885 |
| US-20120263659-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | TRPM8, TRPM7, TRPM2 | TRPM8 1/4885LMNA 1782/4885BCHE 3695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.