Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.51 |
| ▸ | SCD | O00767 | 3/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL1027146 | 0.83 | HRH3 (0.56) | HRH3SCDEPHX2GLS | |
| SCHEMBL1074321 | 0.77 | HRH3 (0.43) | HRH3SCDEPHX2GLS | |
| SCHEMBL1024083 | 0.77 | KDM4E (0.45) | SCDMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1026860 | 0.76 | HRH3 (0.65) | HRH3GLS | |
| SCHEMBL1027045 | 0.75 | MAPT (0.43) | HRH3SCDMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1026463 | 0.72 | FFAR1 (0.45) | HRH3MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1026519 | 0.72 | MAPT (0.40) | HRH3MAPTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL1025527 | 0.72 | MAPT (0.38) | MAPTSMN1; SMN2 | |
| SCHEMBL1025769 | 0.72 | SCD (0.41) | HRH3SCDMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1026902 | 0.72 | HRH3 (0.41) | HRH3MAPTSMN1; SMN2ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009132202-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-10-29 | — | — | WO | disclosed |