Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10272180 | 0.84 | GAA (0.60) | GAAHPGDKMT2ALMNAMEN1 | |
| SCHEMBL2715940 | 0.72 | GAA (0.60) | GAAHPGDKMT2ALMNAMEN1 | |
| SCHEMBL10466353 | 0.72 | GAA (1.00) | GAAHPGDKMT2ALMNAMEN1 | |
| SCHEMBL10271853 | 0.72 | GAA (0.70) | GAAHPGDKMT2ALMNAMEN1 | |
| SCHEMBL213872 | 0.65 | GAA (0.57) | GAAHPGDKMT2ALMNAMEN1 | |
| SCHEMBL8380313 | 0.65 | HPGD (0.65) | GAAHPGDKMT2ALMNAMEN1 | |
| SCHEMBL10272163 | 0.64 | GAA (0.56) | GAAHPGDKMT2ALMNAMEN1 | |
| SCHEMBL10464952 | 0.64 | GAA (0.56) | GAAHPGDKMT2ALMNAMEN1 | |
| SCHEMBL212312 | 0.63 | MEN1 (0.56) | GAAHPGDKMT2ALMNAMEN1 | |
| SCHEMBL214315 | 0.62 | GAA (0.53) | GAAHPGDKMT2ALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |