Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4907452 | 0.73 | MEN1 (0.53) | MEN1KMT2ALMNAHPGDRXFP1 | |
| SCHEMBL10271853 | 0.72 | GAA (0.70) | GAAMEN1KMT2ALMNAHPGD | |
| SCHEMBL10466353 | 0.72 | GAA (1.00) | GAAMEN1KMT2ALMNAHPGD | |
| SCHEMBL10464952 | 0.72 | GAA (0.56) | GAAMEN1KMT2ALMNAHPGD | |
| SCHEMBL4905878 | 0.70 | LMNA (0.56) | MEN1KMT2ALMNAHPGDALDH1A1 | |
| SCHEMBL4906447 | 0.70 | BRD4 (0.55) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL4908900 | 0.70 | HTT (0.60) | GAAMEN1KMT2ALMNAHPGD | |
| SCHEMBL4898304 | 0.69 | ALDH1A1 (0.42) | GAAMEN1KMT2AHPGDRXFP1 | |
| SCHEMBL9639451 | 0.69 | NPSR1 (0.46) | GAAMEN1KMT2ALMNAHPGD | |
| SCHEMBL9640912 | 0.69 | KMT2A (0.45) | GAAMEN1KMT2ALMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |