Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RAPGEF4 | Q8WZA2 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10466353 | 0.72 | GAA (1.00) | GAAPKMMEN1LMNAHPGD | |
| SCHEMBL10271853 | 0.72 | GAA (0.70) | GAAPKMMEN1LMNAHPGD | |
| SCHEMBL10272163 | 0.72 | GAA (0.56) | GAAJAK2JAK1TYK2JAK3 | |
| SCHEMBL7291641 | 0.70 | PKM (0.40) | GAAJAK2JAK1TYK2JAK3 | |
| SCHEMBL15188821 | 0.67 | RAPGEF4 (0.53) | JAK2JAK1TYK2JAK3RAPGEF4 | |
| SCHEMBL10272180 | 0.67 | GAA (0.60) | GAAPKMMEN1LMNAHPGD | |
| SCHEMBL2715940 | 0.67 | GAA (0.60) | GAARAPGEF4MEN1LMNAHPGD | |
| SCHEMBL27389215 | 0.67 | DRD1 (0.47) | MEN1LMNAKMT2AADORA2AADORA2B | |
| SCHEMBL10465098 | 0.66 | USP2 (0.39) | GAAPKMRAPGEF4MEN1LMNA | |
| SCHEMBL15188812 | 0.65 | RAPGEF4 (0.51) | GAAJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4900829-A | 2,4-disubstituted-5-cyano-1,6-dihydro-6-oxo-1-pyrimidineacetic acid aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-02-13 | — | — | US | disclosed |
| US-4786638-A | TREATMENT OR PREVENTION OF DIABETIC COMPLICATIONS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-11-22 | — | — | US | disclosed |