Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.61 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.48 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.46 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17865785 | 0.84 | ADORA2A (0.59) | CNR2ADORA2AEPHX2NR1H4NAMPT | |
| SCHEMBL12388322 | 0.81 | PLK1 (0.59) | ADORA2AEPHX2NR1H4NAMPTHDAC8 | |
| SCHEMBL19197526 | 0.81 | LSS (0.61) | LSSMCHR1MLLT3MLLT1TMEM97 | |
| SCHEMBL507205 | 0.80 | ADORA2A (0.50) | ADORA2AEPHX2NR1H4NAMPTHDAC8 | |
| SCHEMBL10223360 | 0.79 | LSS (0.56) | LSSMCHR1EPHX2NR1H4MLLT3 | |
| SCHEMBL14045108 | 0.79 | MCHR1 (0.62) | LSSMCHR1MLLT3MLLT1TMEM97 | |
| SCHEMBL13113117 | 0.79 | LSS (0.58) | LSSMCHR1EPHX2NR1H4MLLT3 | |
| SCHEMBL6024562 | 0.78 | NPC1 (0.58) | ADORA2ANAMPTHDAC6HTTKMT2A | |
| SCHEMBL13483866 | 0.78 | RAB9A (0.60) | EPHX2NR1H4HDAC8HDAC6HDAC3 | |
| SCHEMBL19197462 | 0.78 | PLK1 (0.63) | LSSMCHR1EPHX2NR1H4HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329726-B2 | Inhibitors of VEGF receptor and HGF receptor signaling | METHYLGENE INC. (CA) | 2012-12-11 | — | — | US | disclosed |
| US-20120083482-A1 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | METHYLGENE INC. | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083482-A1 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | HGF, MET, KDR | LSS 3757/4885MCHR1 158/4885CNR2 233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.