Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | METAP2 | P50579 | 8/20 | 0.35 |
| ▸ | METAP1 | P53582 | 6/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
| ▸ | CAD | P27708 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2982120 | 1.00 | ALOX15 (0.38) | ALOX15ALDH1A1METAP2METAP1LMNA | |
| SCHEMBL17234506 | 0.82 | ALOX15 (0.39) | ALOX15ALDH1A1METAP2METAP1LMNA | |
| SCHEMBL13337460 | 0.82 | ALOX15 (0.39) | ALOX15ALDH1A1METAP2METAP1LMNA | |
| SCHEMBL2888355 | 0.82 | ALOX15 (0.39) | ALOX15ALDH1A1METAP2METAP1LMNA | |
| SCHEMBL2888357 | 0.82 | ALOX15 (0.39) | ALOX15ALDH1A1METAP2METAP1LMNA | |
| SCHEMBL15534315 | 0.80 | ALOX15 (0.38) | ALOX15ALDH1A1METAP2METAP1LMNA | |
| SCHEMBL3906700 | 0.80 | ALOX15 (0.38) | ALOX15ALDH1A1METAP2METAP1LMNA | |
| SCHEMBL5704673 | 0.78 | ALDH1A1 (0.37) | ALOX15ALDH1A1METAP2METAP1LMNA | |
| SCHEMBL3220276 | 0.77 | ALOX15 (0.42) | ALOX15ALDH1A1METAP2METAP1LMNA | |
| SCHEMBL24241888 | 0.76 | ALOX15 (0.34) | ALOX15ALDH1A1METAP2METAP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170349544-A1 | Ethynylbenzene Derivatives | DUKE UNIVERSITY | 2017-12-07 | — | — | US | disclosed |
| US-9738604-B2 | Ethynylbenzene derivatives | DUKE UNIVERSITY (US) | 2017-08-22 | — | — | US | disclosed |
| US-20130231323-A1 | ETHYNYLBENZENE DERIVATIVES | DUKE UNIVERSITY (US) | 2013-09-05 | — | — | US | disclosed |
| WO-2012031298-A2 | ETHYNYLBENZENE DERIVATIVES | DUKE UNIVERSITY (US) | 2012-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170349544-A1 | Ethynylbenzene Derivatives | Q6ZSR9, EPX, ZYX | ALOX15 2030/4885ALDH1A1 1651/4885METAP2 4558/4885 |
| US-20130231323-A1 | ETHYNYLBENZENE DERIVATIVES | Q6ZSR9, EPX, ZYX | ALOX15 2030/4885ALDH1A1 1651/4885METAP2 4558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.