Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL526539 | 0.80 | LTA4H (0.45) | LTA4HNPC1RAB9ACYP11B1CYP11B2 | |
| SCHEMBL12603981 | 0.74 | NPC1 (0.52) | LTA4HNPC1RAB9ACYP11B1CYP11B2 | |
| SCHEMBL11629996 | 0.72 | NPC1 (0.50) | LTA4HNPC1RAB9AIDO1SMN1; SMN2 | |
| SCHEMBL12260768 | 0.69 | NPC1 (0.67) | LTA4HNPC1RAB9AFFAR1CA1 | |
| SCHEMBL19686220 | 0.69 | SCN8A (0.60) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28287823 | 0.69 | LNPEP (0.49) | LTA4HNPC1RAB9ACYP11B1CYP11B2 | |
| SCHEMBL28048769 | 0.69 | CYP11B1 (0.57) | LTA4HNPC1RAB9ACYP11B1CYP11B2 | |
| SCHEMBL9456979 | 0.69 | NPC1 (0.80) | LTA4HNPC1RAB9AFFAR1CA1 | |
| SCHEMBL17912813 | 0.69 | CYP11B1 (0.56) | NPC1RAB9ACYP11B1CYP11B2IDO1 | |
| SCHEMBL1070131 | 0.69 | NPC1 (0.73) | LTA4HNPC1RAB9AFFAR1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012015723-A1 | SULFONAMIDE COMPOUNDS USEFUL AS CYP17 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-02-02 | — | — | WO | disclosed |