Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 11/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.53 |
| ▸ | CYP17A1 | P05093 | 9/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL528008 | 0.83 | PRKCZ (0.61) | CYP11B2CYP11B1CYP17A1CYP3A4PRKCZ | |
| SCHEMBL10094643 | 0.80 | CYP11B2 (0.54) | CYP11B2CYP11B1CYP17A1CYP3A4PRKCZ | |
| SCHEMBL20873066 | 0.77 | PRKCZ (0.64) | CYP11B2CYP11B1CYP17A1CYP3A4PRKCZ | |
| SCHEMBL2382031 | 0.73 | ESR2 (0.38) | CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10304964 | 0.72 | CYP11B2 (0.53) | CYP11B2CYP11B1CYP17A1CYP3A4PRKCZ | |
| SCHEMBL15478218 | 0.72 | TSHR (0.39) | CYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL3298732 | 0.71 | PRKCZ (0.44) | CYP11B2CYP11B1CYP17A1CYP3A4PRKCZ | |
| SCHEMBL19044148 | 0.71 | TYMS (0.38) | CYP11B2CYP11B1CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL27329478 | 0.71 | CYP11B1 (0.53) | CYP11B2CYP11B1CYP17A1CYP3A4PRKCZ | |
| SCHEMBL13798678 | 0.70 | ERN1 (0.56) | CYP11B2CYP11B1CYP17A1CYP3A4PRKCZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012015723-A1 | SULFONAMIDE COMPOUNDS USEFUL AS CYP17 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-02-02 | — | — | WO | disclosed |