Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 10/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.54 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20873066 | 0.85 | PRKCZ (0.64) | CYP11B2CYP11B1PRKCZCYP3A4CYP1A2 | |
| SCHEMBL30283715 | 0.83 | PRKCZ (0.51) | CYP11B2CYP11B1PRKCZCYP3A4CYP1A2 | |
| SCHEMBL528008 | 0.81 | PRKCZ (0.61) | CYP11B2CYP11B1PRKCZCYP3A4CYP1A2 | |
| SCHEMBL10304964 | 0.80 | CYP11B2 (0.53) | CYP11B2CYP11B1PRKCZCYP3A4CYP1A2 | |
| SCHEMBL10272987 | 0.80 | CYP11B2 (0.53) | CYP11B2CYP11B1PRKCZCYP3A4CYP1A2 | |
| SCHEMBL15730740 | 0.79 | KCNA5 (0.48) | CYP11B2CYP11B1PRKCZCYP3A4CYP1A2 | |
| SCHEMBL422347 | 0.77 | CYP2A6 (0.52) | CYP11B2CYP11B1PRKCZCYP3A4CYP1A2 | |
| SCHEMBL2996863 | 0.77 | CYP2A6 (0.65) | CYP1A2ADORA2AALDH1A1CYP2A6 | |
| SCHEMBL5617403 | 0.77 | CYP11B2 (0.53) | CYP11B2CYP11B1PRKCZCYP3A4CYP1A2 | |
| SCHEMBL2203843 | 0.77 | CYP17A1 (0.58) | CYP11B2CYP11B1PRKCZCYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148535-B2 | Potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-04-03 | — | — | US | disclosed |
| US-20090233897-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233897-A1 | Potassium Channel Inhibitors | KCNJ2, KCNQ2, KCNH2 | CYP11B2 2950/4885CYP11B1 3290/4885PRKCZ 1181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.