Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.47 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | USP36 | Q9P275 | 1/20 | 0.45 |
| ▸ | CCR1 | P32246 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL45338 | 0.88 | KDM1A (0.51) | KDM1ANPY5RLMNATRPA1SLC2A1 | |
| SCHEMBL44763 | 0.85 | KDM1A (0.48) | KDM1ANPY5RLMNATRPA1SLC2A1 | |
| SCHEMBL46584 | 0.80 | HSPH1 (0.47) | KDM1ALMNATRPA1MEN1CYP1A2 | |
| SCHEMBL16780930 | 0.79 | LMNA (0.60) | LMNATRPA1MEN1CYP1A2CYP3A4 | |
| SCHEMBL28121166 | 0.77 | MAPT (0.47) | KDM1ANPY5RLMNATRPA1MEN1 | |
| SCHEMBL44915 | 0.75 | LMNA (0.47) | LMNACYP1A2CYP3A4MAPTUSP36 | |
| SCHEMBL28551802 | 0.74 | TRPA1 (0.45) | KDM1ANPY5RTRPA1MEN1CYP1A2 | |
| SCHEMBL46946 | 0.74 | HSPH1 (0.49) | KDM1ALMNATRPA1MEN1CYP1A2 | |
| SCHEMBL16817168 | 0.74 | SLC34A2 (0.42) | KDM1ANPY5RLMNATRPA1MEN1 | |
| SCHEMBL15444454 | 0.73 | HSPH1 (0.44) | KDM1ALMNATRPA1MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |