Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARF6 | P62330 | 4/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10275521 | 0.87 | AR (0.36) | GABRA1GABRG2GABRB3ARGABRA5 | |
| SCHEMBL10276360 | 0.85 | KDM4E (0.36) | GABRA1GABRG2GABRB3ARGABRA5 | |
| SCHEMBL10313576 | 0.84 | ADORA1 (0.40) | GABRA1GABRG2GABRB3GABRA2AR | |
| SCHEMBL10276164 | 0.83 | ARF6 (0.41) | ARF6GABRA1GABRG2GABRB3AR | |
| SCHEMBL10313845 | 0.83 | ARF6 (0.39) | ARF6GABRA1GABRG2GABRB3AR | |
| SCHEMBL10275378 | 0.79 | NPC1 (0.38) | GAAMAPTNPSR1 | |
| SCHEMBL10276268 | 0.78 | ARF6 (0.48) | ARF6GABRA1GABRG2GABRB3GABRA2 | |
| SCHEMBL10275351 | 0.76 | RAD51 (0.35) | GAAMAPTNPSR1 | |
| SCHEMBL10275424 | 0.76 | NPC1 (0.46) | KDM4ENPSR1 | |
| SCHEMBL10276346 | 0.75 | KIF11 (0.43) | ARF6GABRA1GABRG2GABRB3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | XU LIFENG (US) | 2012-07-12 | — | — | US | claimed |
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | XU LIFENG (US) | 2012-07-12 | — | — | US | disclosed |
| WO-2011035518-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | 辽宁利锋科技开发有限公司 (CN) | 2011-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | TYMP, TYMS, ADORA3 | ARF6 3355/4885GABRA1 1257/4885GABRG2 2687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.