Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 15/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10276364 | 0.86 | PGR (0.40) | HSD11B1PGRNR3C2THRB | |
| SCHEMBL10313536 | 0.83 | PGR (0.42) | PGRNR3C2GRM5THRB | |
| SCHEMBL10282694 | 0.83 | HSD11B1 (0.45) | HSD11B1THRBAKR1C3AKR1C2 | |
| SCHEMBL10275794 | 0.82 | PDE2A (0.39) | HSD11B1PGRNR3C2 | |
| SCHEMBL10276685 | 0.78 | HSD11B1 (0.40) | HSD11B1PGRNR3C2AKR1C3AKR1C2 | |
| SCHEMBL10276067 | 0.78 | PGR (0.39) | PGRNR3C2GRM5THRB | |
| SCHEMBL10276402 | 0.77 | PGR (0.35) | PGRNR3C2GRM5 | |
| SCHEMBL10275900 | 0.76 | PGR (0.38) | PGRNR3C2 | |
| SCHEMBL10275276 | 0.76 | HSD11B1 (0.40) | HSD11B1AKR1C3AKR1C2 | |
| SCHEMBL10276305 | 0.76 | MAPT (0.44) | PGRNR3C2AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | XU LIFENG (US) | 2012-07-12 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | TYMP, TYMS, ADORA3 | HSD11B1 831/4885PGR 3472/4885NR3C2 1731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.