SCHEMBL10277311

SCHEMBL10277311

N=C(N)NCCC[C@H](NC(=O)CC1CCCC1)C(=O)O

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ EPHX2 P34913 2/20 0.45
▸ CPB2 Q96IY4 7/20 0.41
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ C3AR1 Q16581 1/20 0.40
▸ GNPAT O15228 1/20 0.39
▸ NMT2 O60551 1/20 0.38
▸ NMT1 P30419 1/20 0.38
▸ CHRNB2 P17787 1/20 0.37
▸ CHRNB4 P30926 1/20 0.37
▸ CHRNA3 P32297 1/20 0.37
▸ CHRNA4 P43681 1/20 0.37
▸ GRIN1 Q05586 1/20 0.37
▸ GRIN2A Q12879 1/20 0.37
▸ GRM1 Q13255 1/20 0.37
▸ KEAP1 Q14145 1/20 0.37
▸ NFE2L2 Q16236 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10277291 0.99 EPHX2 (0.47) EPHX2CPB2SMN1; SMN2C3AR1NMT2
SCHEMBL6561158 0.82 GRIN1 (0.44) EPHX2SMN1; SMN2CHRNB2CHRNB4CHRNA3
SCHEMBL30417895 0.81 CPB2 (0.48) EPHX2CPB2SMN1; SMN2
SCHEMBL8071216 0.81 EPHX2 (0.39) EPHX2CPB2SMN1; SMN2C3AR1GNPAT
SCHEMBL7897054 0.81 EPHX2 (0.44) EPHX2CPB2SMN1; SMN2C3AR1CHRNB2
SCHEMBL17104387 0.81 GRIN1 (0.45) EPHX2CPB2SMN1; SMN2CHRNB2CHRNB4
SCHEMBL6562711 0.81 GRIN1 (0.45) EPHX2CPB2SMN1; SMN2CHRNB2CHRNB4
SCHEMBL17771353 0.80 CPB2 (0.57) CPB2NMT2NMT1
SCHEMBL24961322 0.79 GNPAT (0.45) EPHX2C3AR1GNPAT
SCHEMBL4647818 0.79 C3AR1 (0.45) EPHX2C3AR1GNPAT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10632171-B2 Melanocortin receptor-specific peptides PALATIN TECHNOLOGIES, INC. (US) 2020-04-28 — — US disclosed
US-20190216887-A1 Melanocortin Receptor-Specific Peptides PALATIN TECHNOLOGIES INC (US) 2019-07-18 — — US disclosed
US-9458201-B2 Melanocortin receptor-specific heptapeptides PALATIN TECHNOLOGIES, INC. (US) 2016-10-04 — — US disclosed
US-20140357575-A1 Melanocortin Receptor-Specific Heptapeptides PALATIN TECHNOLOGIES INC (US) 2014-12-04 — — US disclosed
US-8846601-B2 Melanocortin receptor-specific peptides PALATIN TECHNOLOGIES, INC. (US) 2014-09-30 — — US disclosed
US-20120178701-A1 Melanocortin Receptor-Specific Peptides PALATIN TECHNOLOGIES, INC. (US) 2012-07-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140357575-A1 Melanocortin Receptor-Specific Heptapeptides MC5R, MC1R, MC3R EPHX2 2596/4885CPB2 466/4885SMN1; SMN2 1225/4885
US-20190216887-A1 Melanocortin Receptor-Specific Peptides MC1R, MC3R, MC4R EPHX2 3711/4885CPB2 1064/4885SMN1; SMN2 1059/4885
US-10632171-B2 Melanocortin receptor-specific peptides MC1R, MC3R, MC4R EPHX2 3711/4885CPB2 1064/4885SMN1; SMN2 1059/4885
US-20120178701-A1 Melanocortin Receptor-Specific Peptides MC1R, MC3R, MC5R EPHX2 3627/4885CPB2 1299/4885SMN1; SMN2 1366/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback