Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1027788 | 0.86 | LMNA (0.43) | LMNAHTTSMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL1027263 | 0.85 | TOP2A (0.46) | LMNAHTTSMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL1028980 | 0.84 | TOP2A (0.51) | LMNAHTTSMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL1029009 | 0.83 | LMNA (0.40) | LMNAHTTSMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL1026244 | 0.80 | ALDH1A1 (0.53) | LMNAHTTSMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL1025805 | 0.80 | SMN1; SMN2 (0.46) | LMNAHTTSMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL1026536 | 0.78 | NAAA (0.45) | LMNAHTTSMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL3966650 | 0.78 | LMNA (0.56) | LMNAHTTSMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL1027198 | 0.78 | MAPT (0.45) | LMNAHTTSMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL1025204 | 0.77 | MAPT (0.47) | LMNAHTTSMN1; SMN2KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453892-B1 | PHARMACEUTICAL COMPOSITIONS AND THEIR USE FOR TREATING CANCER | INST NAT SANTE RECH MED (FR) | 2013-05-29 | — | — | EP | claimed |
| EP-1608623-B1 | METAL ION CHELATORS AND THERAPEUTIC USE THEREOF | RICHARDSON DESI RAYMOND (AU) | 2011-01-19 | — | — | EP | claimed |