SCHEMBL1028006

SCHEMBL1028006

COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OCc4ccccc4)cc3N)CC2)c(N)cc1OCc1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.53
KMT2A Q03164 2/20 0.53
KDM4E B2RXH2 1/20 0.53
LMNA P02545 1/20 0.53
TSHR P16473 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
TRPC6 Q9Y210 1/20 0.52
NPC1 O15118 2/20 0.50
RAB9A P51151 2/20 0.50
SCN9A Q15858 1/20 0.50
POLB P06746 1/20 0.50
GAA P10253 1/20 0.50
ALDH1A1 P00352 1/20 0.50
ABL1 P00519 1/20 0.50
RIN1 Q13671 1/20 0.50
TLR9 Q9NR96 1/20 0.49
TLR7 Q9NYK1 1/20 0.49
APP P05067 2/20 0.49
SRD5A1 P18405 1/20 0.48
SRD5A2 P31213 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12792438 0.95 NPC1 (0.57) MEN1KMT2AKDM4ELMNATSHR
SCHEMBL12791593 0.94 APP (0.56) MEN1KMT2AKDM4ELMNATSHR
SCHEMBL12791622 0.93 ALDH1A1 (0.52) MEN1KMT2AKDM4ELMNATSHR
SCHEMBL12792444 0.92 HSD17B10 (0.59) MEN1KMT2AKDM4ELMNATSHR
SCHEMBL1026344 0.92 ALDH1A1 (0.55) MEN1KMT2ALMNATSHRNPC1
SCHEMBL1029417 0.91 SLC6A7 (0.56) MEN1KMT2AKDM4ELMNATSHR
SCHEMBL1026312 0.89 ALDH1A1 (0.61) MEN1KMT2AKDM4ELMNATSHR
SCHEMBL1030658 0.86 PDGFRB (0.56) TLR9TLR7
SCHEMBL3138320 0.85 CTSV (0.57) KDM4ESMN1; SMN2NPC1RAB9ASRD5A1
SCHEMBL4728946 0.85 CTSV (0.57) KDM4ESMN1; SMN2NPC1RAB9ASRD5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2150527-B1 ANTHRANILIC ACID DERIVATIVE AS ANTICANCER AGENT AND A PROCESS FOR THE PREPARATION THEREOF COUNCIL SCIENT IND RES (IN) 2011-01-19 EP claimed
EP-2150527-A2 ANTHRANILIC ACID DERIVATIVE AS ANTICANCER AGENT AND A PROCESS FOR THE PREPARATION THEREOF Council of Scientific & Industrial Research (IN) 2010-02-10 EP claimed
US-20100016589-A1 Novel Anthranilic Acid Derivative as Potential Anticancer Agent and a Process for the Preparation Thereof COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2010-01-21 US claimed
WO-2008114275-A2 ANTHRANILIC ACID DERIVATIVES AS ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2008-09-25 WO claimed
US-8309726-B2 Substituted piperazine compounds of formula 8 COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2012-11-13 US disclosed
EP-2150527-B1 ANTHRANILIC ACID DERIVATIVE AS ANTICANCER AGENT AND A PROCESS FOR THE PREPARATION THEREOF COUNCIL SCIENT IND RES (IN) 2011-01-19 EP disclosed
EP-2150527-A2 ANTHRANILIC ACID DERIVATIVE AS ANTICANCER AGENT AND A PROCESS FOR THE PREPARATION THEREOF Council of Scientific & Industrial Research (IN) 2010-02-10 EP disclosed
US-20100016589-A1 Novel Anthranilic Acid Derivative as Potential Anticancer Agent and a Process for the Preparation Thereof COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2010-01-21 US disclosed
WO-2008114275-A2 ANTHRANILIC ACID DERIVATIVES AS ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2008-09-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100016589-A1 Novel Anthranilic Acid Derivative as Potential Anticancer Agent and a Process for the Preparation Thereof AADAC, API5, APEH MEN1 3412/4885KMT2A 191/4885KDM4E 236/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.