Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | SGMS2 | Q8NHU3 | 3/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14987958 | 0.85 | KCNMA1 (0.48) | KCNMA1CYP11B2LMNAHPGDFFAR2 | |
| SCHEMBL10308272 | 0.79 | EHMT2 (0.49) | KCNMA1CYP11B2LMNAHPGDFFAR2 | |
| SCHEMBL823592 | 0.78 | HDAC3 (0.56) | KCNMA1CYP11B2LMNAKMT2AMEN1 | |
| SCHEMBL19592331 | 0.74 | KMT2A (0.60) | LMNAFFAR2KMT2AMEN1RAB9A | |
| SCHEMBL18661183 | 0.72 | NAMPT (0.60) | HPGDKMT2AMEN1MAPTRAB9A | |
| SCHEMBL24688163 | 0.70 | LMNA (0.62) | LMNAKMT2AMEN1MAPTRAB9A | |
| SCHEMBL21755225 | 0.69 | LMNA (0.56) | LMNAFFAR2KMT2AMEN1RAB9A | |
| SCHEMBL21507660 | 0.68 | CYP11B2 (0.73) | KCNMA1CYP11B2GRIK1KMT2AMEN1 | |
| SCHEMBL829775 | 0.66 | EHMT2 (0.54) | LMNAKMT2AMEN1RAB9ANPC1 | |
| SCHEMBL830026 | 0.66 | EHMT2 (0.46) | KMT2AMEN1MAPTALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178783-A1 | HDAC INHIBITORS | LIXTE BIOTECHNOLOGY, INC. | 2012-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178783-A1 | HDAC INHIBITORS | HDAC3, HDAC4, HDAC7 | KCNMA1 2959/4885CYP11B2 2940/4885LMNA 2276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.