Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 8/20 | 0.58 |
| ▸ | NPC1 | O15118 | 7/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | GCK | P35557 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1506579 | 1.00 | PDK1 (0.58) | PDK1RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1028051 | 1.00 | PDK1 (0.58) | PDK1RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1033938 | 0.88 | SMN1; SMN2 (0.56) | PDK1RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1031917 | 0.85 | RAB9A (0.57) | PDK1RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1031919 | 0.85 | RAB9A (0.57) | PDK1RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1506733 | 0.85 | RAB9A (0.57) | PDK1RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3537545 | 0.84 | PDK1 (0.56) | PDK1RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1032199 | 0.82 | PDK1 (0.65) | PDK1RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| Bromide SCHEMBL3055052 | 0.81 | PDK1 (0.64) | PDK1RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3562143 | 0.81 | NPC1 (0.52) | RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730129-B1 | INTERMEDIATES FOR THE PREPARATION OF PRAMIPEXOLE | DIPHARMA FRANCIS SRL (IT) | 2011-01-19 | — | — | EP | claimed |
| US-20070191439-A1 | Intermediates for the preparation of pramipexole | DIPHARMA S.P.A. (IT) | 2007-08-16 | — | — | US | claimed |
| EP-1730129-A2 | INTERMEDIATES FOR THE PREPARATION OF PRAMIPEXOLE | Dipharma S.p.A. (IT) | 2006-12-13 | — | — | EP | claimed |
| WO-2005092871-A2 | INTERMEDIATES FOR THE PREPARATION OF PRAMIPEXOLE | DIPHARMA S.P.A. (IT) | 2005-10-06 | — | — | WO | claimed |
| US-8203002-B2 | Intermediates for the preparation of pramipexole | DIPHARMA S.P.A. (IT) | 2012-06-19 | — | — | US | disclosed |
| EP-2289885-A1 | Intermediates for the preparation of pramipexole | Dipharma Francis S.r.l. (IT) | 2011-03-02 | — | — | EP | disclosed |
| EP-1730129-B1 | INTERMEDIATES FOR THE PREPARATION OF PRAMIPEXOLE | DIPHARMA FRANCIS SRL (IT) | 2011-01-19 | — | — | EP | disclosed |
| US-20100222595-A1 | INTERMEDIATES FOR THE PREPARATION OF PRAMIPEXOLE | DIPHARMA S.P.A. (IT) | 2010-09-02 | — | — | US | disclosed |
| US-7741490-B2 | Intermediates for the preparation of pramipexole | DIPHARMA S.P.A. (IT) | 2010-06-22 | — | — | US | disclosed |
| US-7662610-B2 | Synthesis of intermediates for the preparation of pramipexol | DIPHARMA FRANCIS S.R.L. (IT) | 2010-02-16 | — | — | US | disclosed |
| US-20070191439-A1 | Intermediates for the preparation of pramipexole | DIPHARMA S.P.A. (IT) | 2007-08-16 | — | — | US | disclosed |
| US-20070166814-A1 | SYNTHESIS OF INTERMEDIATES FOR THE PREPARATION OF PRAMIPEXOL | DIPHARMA FRANCIS S.R.L. (IT) | 2007-07-19 | — | — | US | disclosed |
| EP-1808492-A1 | Synthesis of intermediates for the preparation of pramipexol | Dipharma Francis S.r.l. (IT) | 2007-07-18 | — | — | EP | disclosed |
| EP-1730129-A2 | INTERMEDIATES FOR THE PREPARATION OF PRAMIPEXOLE | Dipharma S.p.A. (IT) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005092871-A2 | INTERMEDIATES FOR THE PREPARATION OF PRAMIPEXOLE | DIPHARMA S.P.A. (IT) | 2005-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222595-A1 | INTERMEDIATES FOR THE PREPARATION OF PRAMIPEXOLE | CYP11B2, CYP11B1, CYP4A11 | PDK1 288/4885RAB9A 3119/4885NPC1 1798/4885 |
| US-20070191439-A1 | Intermediates for the preparation of pramipexole | CYP11B2, CYP11B1, CYP4A11 | PDK1 288/4885RAB9A 3119/4885NPC1 1798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.