Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.36 |
| ▸ | UBE2M | P61081 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 3/20 | 0.34 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1028055 | 1.00 | MMP1 (0.37) | MMP1MMP2MMP9MMP8MMP13 | |
| SCHEMBL4367032 | 0.82 | SIRT2 (0.40) | SIRT2ALDH1A1SIRT1DRD2POLB | |
| SCHEMBL4367036 | 0.82 | SIRT2 (0.40) | SIRT2ALDH1A1SIRT1DRD2POLB | |
| SCHEMBL13623226 | 0.82 | SIRT2 (0.40) | MMP1MMP2MMP9MMP8MMP13 | |
| SCHEMBL1026372 | 0.80 | LMNA (0.40) | MMP1MMP2MMP9MMP8MMP13 | |
| SCHEMBL13623213 | 0.80 | MAPT (0.46) | SIRT2ALDH1A1POLBKMT2A | |
| SCHEMBL13623216 | 0.79 | ALDH1A1 (0.52) | WDR5ALDH1A1POLBKMT2A | |
| SCHEMBL1083487 | 0.75 | TLR7 (0.37) | UBE2MDCUN1D1RORCDRD2 | |
| SCHEMBL1027144 | 0.74 | HTT (0.42) | WDR5UBE2MDCUN1D1ALDH1A1KMT2A | |
| SCHEMBL1027142 | 0.74 | HTT (0.42) | WDR5UBE2MDCUN1D1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009132202-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-10-29 | — | — | WO | disclosed |