Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 5/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 4/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.37 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.37 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.37 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | TERT | O14746 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | DTYMK | P23919 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL220290 | 0.88 | SMARCA2 (0.44) | ACKR3CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL27714533 | 0.73 | SMN1; SMN2 (0.35) | KDM4EALDH1A1 | |
| SCHEMBL220889 | 0.71 | SIRT1 (0.47) | ACKR3CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL21579067 | 0.71 | ACKR3 (0.49) | ACKR3CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL22221684 | 0.71 | ACKR3 (0.71) | ACKR3CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL27923722 | 0.71 | ALDH1A1 (0.35) | KDM4EALDH1A1 | |
| SCHEMBL2734028 | 0.69 | ALDH1A1 (0.60) | ACKR3CHRM2CHRM4CHRM1CHRM3 | |
| Tert-Butyl Formate SCHEMBL27714534 | 0.68 | SIRT1 (0.39) | CHRM2CHRM1KDM4EALDH1A1 | |
| SCHEMBL465777 | 0.68 | SMN1; SMN2 (0.51) | ACKR3CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL16061780 | 0.68 | FAAH (0.58) | ACKR3CHRM2CHRM4CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093401-B2 | Silent Information Regulators; aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting , increased mitochondrial activity, inflammation, cancer, and/or flushing; increased lifespan specially in mutant sir2 strains; imidazo[1,2-a]pyridine drivatives | SIRTRIS PHARMACEUTICALS, INC. (US) | 2012-01-10 | — | — | US | disclosed |
| US-7855289-B2 | histone deacetylase inhibitors, used for treating preventing diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood disorders, inflammation, cancer, and/or hot flashes | SIRTRIS PHARMACEUTICALS, INC. (US) | 2010-12-21 | — | — | US | disclosed |