Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.42 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1028886 | 1.00 | L3MBTL1 (0.49) | L3MBTL1SMN1; SMN2ALDH1A1TP53GPR35 | |
| SCHEMBL16735812 | 0.84 | ALDH1A1 (0.44) | L3MBTL1ALDH1A1TP53TSHRGAA | |
| SCHEMBL17099460 | 0.84 | ALDH1A1 (0.44) | L3MBTL1ALDH1A1TP53TSHRGAA | |
| SCHEMBL3509375 | 0.84 | ALDH1A1 (0.46) | L3MBTL1ALDH1A1TP53TSHRGAA | |
| SCHEMBL3509381 | 0.84 | ALDH1A1 (0.46) | L3MBTL1ALDH1A1TP53TSHRGAA | |
| SCHEMBL2209277 | 0.82 | ALDH1A1 (0.56) | L3MBTL1SMN1; SMN2ALDH1A1MAPK1GAA | |
| SCHEMBL2209281 | 0.82 | ALDH1A1 (0.56) | L3MBTL1SMN1; SMN2ALDH1A1MAPK1GAA | |
| SCHEMBL1026262 | 0.81 | ALDH1A1 (0.48) | L3MBTL1SMN1; SMN2ALDH1A1TP53HPGD | |
| SCHEMBL1026260 | 0.81 | ALDH1A1 (0.48) | L3MBTL1SMN1; SMN2ALDH1A1TP53HPGD | |
| SCHEMBL20494421 | 0.80 | L3MBTL1 (0.56) | L3MBTL1SMN1; SMN2ALDH1A1TP53GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |