Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 2/20 | 0.56 |
| ▸ | XDH | P47989 | 2/20 | 0.56 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10288996 | 0.82 | MPO (0.54) | MPOXDHCA12CA1CA2 | |
| SCHEMBL15215603 | 0.76 | MPO (0.59) | MPOXDHCA12CA1CA2 | |
| SCHEMBL2730985 | 0.74 | KMT2A (0.67) | MPOXDHMEN1KMT2ARXFP1 | |
| SCHEMBL2731141 | 0.72 | MPO (1.00) | MPOXDHMEN1KMT2ARXFP1 | |
| SCHEMBL4104209 | 0.71 | KDM4E (0.47) | CA12PKMSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL15215604 | 0.70 | MPO (0.67) | MPOXDHCA12CA1CA2 | |
| SCHEMBL13701237 | 0.60 | AXL (0.41) | MEN1KMT2AMAPTPKMSMN1; SMN2 | |
| SCHEMBL84762 | 0.58 | MAOA (0.33) | SMN1; SMN2ALDH1A1HTTKDM4E | |
| SCHEMBL13323483 | 0.58 | MEN1 (0.51) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL8424756 | 0.58 | IDO1 (0.54) | CA12CA1CA2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012058211-A2 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2012-05-03 | — | — | WO | disclosed |