Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 1/20 | 0.53 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.51 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.51 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25168671 | 0.98 | TSHR (0.59) | TSHRLTA4HSMPD1PLA2G4BTBXAS1 | |
| SCHEMBL6960220 | 0.98 | TSHR (0.59) | TSHRLTA4HSMPD1PLA2G4BTBXAS1 | |
| SCHEMBL14034743 | 0.98 | TSHR (0.59) | TSHRLTA4HSMPD1PLA2G4BTBXAS1 | |
| SCHEMBL6957299 | 0.98 | TSHR (0.59) | TSHRLTA4HSMPD1PLA2G4BTBXAS1 | |
| SCHEMBL1070542 | 0.95 | CYP11B1 (0.55) | TSHRLTA4HPLA2G4BTBXAS1CYP11B1 | |
| SCHEMBL2536496 | 0.90 | KMT2A (0.54) | TSHRTBXAS1CYP11B1CYP11B2 | |
| SCHEMBL7388461 | 0.90 | TBXAS1 (0.56) | TBXAS1 | |
| SCHEMBL921871 | 0.89 | LTA4H (0.56) | TSHRLTA4HPLA2G4BTBXAS1CYP11B1 | |
| SCHEMBL921023 | 0.87 | LTA4H (0.62) | LTA4HTBXAS1CYP11B1CYP11B2KDM4E | |
| SCHEMBL12879202 | 0.86 | CYP11B1 (0.57) | TSHRLTA4HPLA2G4BCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953148-B1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2012-02-29 | — | — | EP | disclosed |