Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ESRRA | P11474 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10290589 | 0.83 | MAPT (0.40) | LMNAMAPTALDH1A1CYP3A4AR | |
| SCHEMBL12697290 | 0.81 | AR (0.40) | LMNAHTTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL1301464 | 0.79 | PKM (0.47) | LMNAHTTMAPTALDH1A1CYP3A4 | |
| SCHEMBL3987655 | 0.78 | MAPT (0.45) | LMNAHTTMAPTALDH1A1CYP3A4 | |
| SCHEMBL1301766 | 0.78 | CHEK1 (0.46) | LMNAHTTMAPTALDH1A1CYP3A4 | |
| SCHEMBL1098691 | 0.77 | LMNA (0.54) | LMNAHTTMAPTALDH1A1CYP3A4 | |
| SCHEMBL31451515 | 0.77 | HTT (0.49) | LMNAHTTMAPTALDH1A1CYP3A4 | |
| SCHEMBL397099 | 0.77 | LMNA (0.47) | LMNAHTTMAPTALDH1A1CYP3A4 | |
| SCHEMBL26426262 | 0.75 | ALDH1A1 (0.43) | LMNAHTTMAPTALDH1A1CYP3A4 | |
| SCHEMBL29559705 | 0.75 | ALDH1A1 (0.43) | LMNAHTTMAPTALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2522659-A2 | Modulators of ATP-binding cassette transporters | Vertex Pharmaceuticals Incorporated (US) | 2012-11-14 | — | — | EP | disclosed |