Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6467142 | 0.97 | PDE10A (0.49) | PDE10AMAPTHPGDALDH1A1KDM4E | |
| SCHEMBL3506829 | 0.93 | PDE10A (0.51) | PDE10AMAPTHPGDALDH1A1KDM4E | |
| SCHEMBL15105014 | 0.80 | ALDH1A1 (0.35) | PDE10AMAPTALDH1A1KDM4ENPC1 | |
| SCHEMBL166920 | 0.74 | — | — | |
| SCHEMBL6646933 | 0.74 | NPC1 (0.43) | PDE10AMAPTHPGDALDH1A1KDM4E | |
| SCHEMBL4173347 | 0.72 | PDE10A (0.36) | PDE10ARAB9AKCNH2HRH3TSHR | |
| SCHEMBL4064733 | 0.72 | SMO (0.49) | PDE10ANPC1RAB9ASMOSMN1; SMN2 | |
| SCHEMBL3508532 | 0.72 | PDE10A (0.40) | PDE10AMAPTHPGDALDH1A1NPC1 | |
| SCHEMBL8345825 | 0.70 | RAB9A (0.51) | MAPTHPGDALDH1A1NPC1RAB9A | |
| SCHEMBL5516961 | 0.70 | PDE10A (0.40) | PDE10AMAPTALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054510-A1 | OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |