Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.68 |
| ▸ | MAOB | P27338 | 1/20 | 0.68 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.65 |
| ▸ | DRD2 | P14416 | 4/20 | 0.63 |
| ▸ | DRD4 | P21917 | 3/20 | 0.63 |
| ▸ | DRD3 | P35462 | 3/20 | 0.63 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.59 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7383661 | 0.98 | MAOA (0.66) | MAOAMAOBGRIN2BDRD2DRD4 | |
| SCHEMBL4859978 | 0.86 | GRIN2B (0.55) | MAOAMAOBGRIN2BDRD2DRD4 | |
| SCHEMBL8393323 | 0.86 | GRIN2B (0.67) | MAOAMAOBGRIN2BDRD2DRD4 | |
| SCHEMBL31208094 | 0.86 | GRIN2B (0.67) | MAOAMAOBGRIN2BDRD2DRD4 | |
| SCHEMBL29588340 | 0.86 | GRIN2B (0.67) | MAOAMAOBGRIN2BDRD2DRD4 | |
| SCHEMBL2597220 | 0.86 | GRIN2B (0.67) | MAOAMAOBGRIN2BDRD2DRD4 | |
| SCHEMBL2598589 | 0.86 | GRIN2B (0.67) | MAOAMAOBGRIN2BDRD2DRD4 | |
| Hydrochloric Acid SCHEMBL7935272 | 0.84 | GRIN2B (0.65) | MAOAMAOBGRIN2BDRD2DRD4 | |
| Hydrochloric Acid SCHEMBL1026811 | 0.84 | GRIN2B (0.53) | MAOAMAOBGRIN2BDRD2DRD4 | |
| Benzene SCHEMBL27334501 | 0.82 | GRIN2B (0.56) | MAOAMAOBGRIN2BDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11198685-B2 | Substituted ureas and methods of making and using same | MEBIAS DISCOVERY, INC. (US) | 2021-12-14 | — | — | US | disclosed |
| US-20200308155-A1 | Substituted Ureas and Methods of Making and Using Same | MEBIAS DISCOVERY, INC. | 2020-10-01 | — | — | US | disclosed |
| US-8211935-B2 | Heterocyclic derivatives for modulation of calcium channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-07-03 | — | — | US | disclosed |
| US-20110178061-A1 | HETEROCYCLIC DERIVATIVES FOR MODULATION OF CALCIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-21 | — | — | US | disclosed |
| US-7569604-B2 | Heterocyclic derivatives for modulation of calcium channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-08-04 | — | — | US | disclosed |
| US-4239903-A | ANTISPASMODIC AGENTS | DAIICHI SEIYAKU CO., LTD. (JP) | 1980-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178061-A1 | HETEROCYCLIC DERIVATIVES FOR MODULATION OF CALCIUM CHANNELS | CACNA1D, ORAI1, CACNA1C | MAOA 1820/4885MAOB 2236/4885GRIN2B 234/4885 |
| US-11198685-B2 | Substituted ureas and methods of making and using same | UMPS, METTL3, UTS2R | MAOA 1229/4885MAOB 1382/4885GRIN2B 3350/4885 |
| US-20200308155-A1 | Substituted Ureas and Methods of Making and Using Same | UMPS, METTL3, UTS2R | MAOA 1229/4885MAOB 1382/4885GRIN2B 3350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.