Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.45 |
| ▸ | VEGFA | P15692 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 7/20 | 0.43 |
| ▸ | MMP9 | P14780 | 7/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 5/20 | 0.39 |
| ▸ | IL1RN | P18510 | 3/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24067446 | 0.78 | EGLN1 (0.51) | EGLN1VEGFAMMP2MMP9ERAP2 | |
| SCHEMBL2645984 | 0.76 | EGLN1 (0.56) | EGLN1VEGFAMMP2MMP9ERAP2 | |
| SCHEMBL10465376 | 0.74 | EGLN1 (0.54) | EGLN1VEGFAMMP2MMP9ERAP2 | |
| SCHEMBL9453904 | 0.74 | EGLN1 (0.54) | EGLN1VEGFAMMP2MMP9ERAP2 | |
| SCHEMBL9453861 | 0.73 | EGLN1 (0.53) | EGLN1VEGFAMMP2MMP9ERAP2 | |
| SCHEMBL13036960 | 0.71 | EGLN1 (0.51) | EGLN1VEGFAMMP2MMP9ERAP2 | |
| SCHEMBL7256310 | 0.70 | PARP1 (0.55) | EGLN1VEGFAMMP2MMP9ERAP2 | |
| SCHEMBL9453852 | 0.70 | ALDH1A1 (0.54) | EGLN1VEGFAMMP2MMP9NPC1 | |
| SCHEMBL5179205 | 0.69 | EGLN1 (0.53) | EGLN1VEGFAMMP2MMP9ERAP2 | |
| SCHEMBL16088173 | 0.69 | ALDH1A1 (0.49) | EGLN1VEGFAMMP2MMP9NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9156772-B2 | Fluoride-releasing compositions | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-10-13 | — | — | US | disclosed |
| US-20140088308-A1 | Fluoride-Releasing Compositions | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2014-03-27 | — | — | US | disclosed |
| US-20120264939-A1 | Fluoride-Releasing Compositions | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-10-18 | — | — | US | disclosed |
| US-8217173-B2 | Fluoride-releasing compositions | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2012-07-10 | — | — | US | disclosed |
| US-20100261902-A1 | Fluoride-Releasing Compositions | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY (US) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140088308-A1 | Fluoride-Releasing Compositions | CHERP, ORAI1, CAD | EGLN1 2227/4885VEGFA 4288/4885MMP2 930/4885 |
| US-20120264939-A1 | Fluoride-Releasing Compositions | CHERP, ORAI1, CAD | EGLN1 2227/4885VEGFA 4288/4885MMP2 930/4885 |
| US-20100261902-A1 | Fluoride-Releasing Compositions | CHERP, ORAI1, CAD | EGLN1 2227/4885VEGFA 4288/4885MMP2 930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.