Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MYC | P01106 | 2/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.35 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | F3 | P13726 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL823686 | 0.83 | ALDH1A1 (0.61) | ALDH1A1TP53GAATSHRCA1 | |
| SCHEMBL27893968 | 0.80 | TSHR (0.58) | ALDH1A1TP53GAATSHRCA1 | |
| SCHEMBL10307884 | 0.78 | POLB (0.45) | ALDH1A1SMN1; SMN2POLBKDM4EHSD17B10 | |
| SCHEMBL12052833 | 0.75 | PTGER1 (0.49) | ALDH1A1TP53GAATSHRCA1 | |
| SCHEMBL11704995 | 0.73 | CYP3A4 (0.50) | ALDH1A1TP53GAATSHRCA1 | |
| SCHEMBL10307880 | 0.73 | POLB (0.65) | ALDH1A1TSHRCA1CA2SMN1; SMN2 | |
| SCHEMBL4437995 | 0.72 | ALDH1A1 (0.61) | ALDH1A1TP53GAATSHRCA1 | |
| SCHEMBL12565537 | 0.71 | AKR1C4 (0.41) | ALDH1A1TP53GAATSHRCA1 | |
| SCHEMBL20053804 | 0.70 | ALDH1A1 (0.57) | ALDH1A1TP53GAATSHRCA1 | |
| SCHEMBL826739 | 0.69 | SMN1; SMN2 (0.61) | ALDH1A1TP53TSHRCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455688-B2 | HDAC inhibitors | LIXTE BIOTECHNOLOGY, INC. (US) | 2013-06-04 | — | — | US | disclosed |
| US-20120178783-A1 | HDAC INHIBITORS | LIXTE BIOTECHNOLOGY, INC. | 2012-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178783-A1 | HDAC INHIBITORS | HDAC3, HDAC4, HDAC7 | ALDH1A1 2826/4885TP53 795/4885GAA 4142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.