Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MYC | P01106 | 2/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | F7 | P08709 | 1/20 | 0.46 |
| ▸ | F3 | P13726 | 1/20 | 0.46 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4437995 | 0.88 | ALDH1A1 (0.61) | ALDH1A1TP53CA1CA2TSHR | |
| SCHEMBL20053804 | 0.84 | ALDH1A1 (0.57) | ALDH1A1TP53CA1CA2TSHR | |
| SCHEMBL11285580 | 0.83 | ALDH1A1 (0.45) | ALDH1A1TP53CA1CA2TSHR | |
| SCHEMBL826739 | 0.83 | SMN1; SMN2 (0.61) | ALDH1A1TP53CA1CA2TSHR | |
| SCHEMBL10307883 | 0.83 | ALDH1A1 (0.44) | ALDH1A1TP53CA1CA2TSHR | |
| SCHEMBL11377040 | 0.82 | KDM4E (0.53) | ALDH1A1TP53CA1CA2TSHR | |
| SCHEMBL8530466 | 0.81 | ALDH1A1 (0.58) | ALDH1A1TP53CA1CA2TSHR | |
| SCHEMBL8533569 | 0.80 | HPGD (0.68) | ALDH1A1TP53CA1CA2TSHR | |
| SCHEMBL11096506 | 0.80 | ALDH1A1 (0.52) | ALDH1A1TP53CA1CA2TSHR | |
| SCHEMBL4439475 | 0.80 | KDM4E (0.57) | ALDH1A1TP53CA1CA2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200439-B1 | HDAC INHIBITORS | LIXTE BIOTECHNOLOGY INC (US) | 2017-03-22 | — | — | EP | disclosed |
| EP-1425262-B1 | Acylthiols and compositions thereof as anti-HIV and anti-retroviral agents | GOV OF USA AS REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES NAT INST OF HEALTH (US) | 2014-01-08 | — | — | EP | disclosed |
| US-8455688-B2 | HDAC inhibitors | LIXTE BIOTECHNOLOGY, INC. (US) | 2013-06-04 | — | — | US | disclosed |
| US-20120178783-A1 | HDAC INHIBITORS | LIXTE BIOTECHNOLOGY, INC. | 2012-07-12 | — | — | US | disclosed |
| US-8143445-B2 | HDAC inhibitors | LIXTE BIOTECHNOLOGY, INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143445-B2 | HDAC inhibitors | LIXTE BIOTECHNOLOGY, INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-8076372-B2 | Acythiols and component thiol compositions as anti-HIV and anti-retroviral agents | GOVERNMENT OF THE UNITED STATES (US) | 2011-12-13 | — | — | US | disclosed |
| US-20090247473-A1 | ACYTHIOLS AND COMPONENT THIOL COMPOSITIONS AS ANTI-HIV AND ANTI-RETROVIRAL AGENTS | THE GOVERNMENT OF THE U.S.A.,AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH & HUMAN SERVICES (US) | 2009-10-01 | — | — | US | disclosed |
| US-20090143445-A1 | HDAC Inhibitors | JOHN P. WHITE, ESQ | 2009-06-04 | — | — | US | disclosed |
| US-7528274-B2 | Acylthiols and component thiol compositions as anti-HIV and anti-retroviral agents | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-05-05 | — | — | US | disclosed |
| US-7015212-B1 | Thiazepine inhibitors of HIV-1 integrase | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2006-03-21 | — | — | US | disclosed |
| EP-1425262-A4 | ACYLTHIOLS AND COMPONENT THIOL COMPOSITIONS AS ANTI-HIV AND ANTI-RETROVIRAL AGENTS | US GOV HEALTH & HUMAN SERV (US) | 2006-03-08 | — | — | EP | disclosed |
| US-20050020831-A1 | Acylthiols and component thiol compositions as anti-hiv and anti-retroviral agents | GOVERNMENT OF THE UNITED STATES | 2005-01-27 | — | — | US | disclosed |
| EP-1425262-A1 | ACYLTHIOLS AND COMPONENT THIOL COMPOSITIONS AS ANTI-HIV AND ANTI-RETROVIRAL AGENTS | The Gov. of USA, as represented by the Secretary, Dept. of Health and Human services, National Institutes of Health (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003014062-A1 | ACYLTHIOLS AND COMPONENT THIOL COMPOSITIONS AS ANTI-HIV AND ANTI-RETROVIRAL AGENTS | THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2003-02-20 | — | — | WO | disclosed |
| EP-1187837-A1 | THIAZEPINE INHIBITORS OF HIV-1 INTEGRASE | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000068235-A1 | THIAZEPINE INHIBITORS OF HIV-1 INTEGRASE | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES, THE NATIONAL INSTITUTES OF HEALTH (US) | 2000-11-16 | — | — | WO | disclosed |
| WO-1993012080-A1 | SUBSTITUTED DIPHENYLSULFIDES AS SEROTONIN UPTAKE INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-06-24 | — | — | WO | disclosed |
| US-4272531-A | ENZYME INHIBITORS | SMITHKLINE CORPORATION (US) | 1981-06-09 | — | — | US | disclosed |
| US-4101558-A | Process for preparing thioxanthones | THE SHERWIN-WILLIAMS COMPANY (US) | 1978-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178783-A1 | HDAC INHIBITORS | HDAC3, HDAC4, HDAC7 | ALDH1A1 2826/4885TP53 795/4885CA1 1452/4885 |
| US-20090143445-A1 | HDAC Inhibitors | HDAC3, HDAC7, HDAC4 | ALDH1A1 2891/4885TP53 760/4885CA1 1408/4885 |
| US-20090247473-A1 | ACYTHIOLS AND COMPONENT THIOL COMPOSITIONS AS ANTI-HIV AND ANTI-RETROVIRAL AGENTS | ZC3HAV1, ZFP3, ATL3 | ALDH1A1 1936/4885TP53 1134/4885CA1 3286/4885 |
| US-20050020831-A1 | Acylthiols and component thiol compositions as anti-hiv and anti-retroviral agents | ZC3HAV1, ACAT2, ACAT1 | ALDH1A1 2593/4885TP53 1427/4885CA1 3411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.