Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SDCBP | O00560 | 2/20 | 0.38 |
| ▸ | SDC2 | P34741 | 2/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | C1R | P00736 | 1/20 | 0.36 |
| ▸ | C1S | P09871 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10308680 | 1.00 | LMNA (0.41) | LMNAMBTPS1MAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10308604 | 0.84 | SLC22A12 (0.36) | LMNAMBTPS1MAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10308619 | 0.84 | SLC22A12 (0.36) | LMNAMBTPS1MAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10308411 | 0.84 | SDCBP (0.44) | LMNAMBTPS1ALDH1A1SMN1; SMN2SDCBP | |
| SCHEMBL12836919 | 0.84 | SDCBP (0.44) | LMNAMBTPS1ALDH1A1SMN1; SMN2SDCBP | |
| SCHEMBL10308444 | 0.82 | SDCBP (0.39) | LMNAMBTPS1MAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL806885 | 0.82 | AKR1B1 (0.47) | LMNAMAPK1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL405981 | 0.81 | MAPK1 (0.44) | LMNAMAPK1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL12835752 | 0.81 | SDCBP (0.37) | LMNAMBTPS1ALDH1A1SDCBPSDC2 | |
| SCHEMBL12835750 | 0.81 | SDCBP (0.37) | LMNAMBTPS1ALDH1A1SDCBPSDC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178666-A1 | PRODRUGS OF GUANFACINE | SHIRE LLC (US) | 2012-07-12 | — | — | US | disclosed |
| WO-2011033296-A1 | PRODRUGS OF GUANFACINE | SHIRE LLC (US) | 2011-03-24 | — | — | WO | disclosed |
| US-20110065796-A1 | PRODRUGS OF GUANFACINE | SHIRE LLC (US) | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178666-A1 | PRODRUGS OF GUANFACINE | DNPEP, VIP, GDA | LMNA 4311/4885MBTPS1 2486/4885MAPK1 3325/4885 |
| US-20110065796-A1 | PRODRUGS OF GUANFACINE | DNPEP, VIP, GDA | LMNA 4311/4885MBTPS1 2486/4885MAPK1 3325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.