Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SDCBP | O00560 | 2/20 | 0.37 |
| ▸ | SDC2 | P34741 | 2/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | C1R | P00736 | 1/20 | 0.35 |
| ▸ | C1S | P09871 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | PYGL | P06737 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12835750 | 1.00 | SDCBP (0.37) | SDCBPSDC2SLC22A12MMEKMT2A | |
| SCHEMBL10308604 | 0.84 | SLC22A12 (0.36) | SDCBPSDC2SLC22A12MMEKMT2A | |
| SCHEMBL10308619 | 0.84 | SLC22A12 (0.36) | SDCBPSDC2SLC22A12MMEKMT2A | |
| SCHEMBL10308411 | 0.83 | SDCBP (0.44) | SDCBPSDC2SLC22A12KMT2AAKR1B1 | |
| SCHEMBL12836919 | 0.83 | SDCBP (0.44) | SDCBPSDC2SLC22A12KMT2AAKR1B1 | |
| SCHEMBL10308444 | 0.82 | SDCBP (0.39) | SDCBPSDC2SLC22A12KMT2AAKR1B1 | |
| SCHEMBL10308680 | 0.81 | LMNA (0.41) | SDCBPSDC2SLC22A12KMT2AAKR1B1 | |
| SCHEMBL10308583 | 0.81 | LMNA (0.41) | SDCBPSDC2SLC22A12KMT2AAKR1B1 | |
| SCHEMBL8744811 | 0.80 | SDCBP (0.51) | SDCBPSDC2SLC22A12KMT2AAKR1B1 | |
| SCHEMBL8744816 | 0.80 | SDCBP (0.51) | SDCBPSDC2SLC22A12KMT2AAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110065796-A1 | PRODRUGS OF GUANFACINE | SHIRE LLC (US) | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065796-A1 | PRODRUGS OF GUANFACINE | DNPEP, VIP, GDA | SDCBP 4078/4885SDC2 3838/4885SLC22A12 644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.