Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.71 |
| ▸ | MEN1 | O00255 | 5/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10309073 | 0.87 | ALDH1A1 (0.76) | ALDH1A1NPSR1KMT2AMEN1MAPK1 | |
| SCHEMBL30044536 | 0.85 | ALDH1A1 (0.74) | ALDH1A1NPSR1KMT2AMEN1MAPK1 | |
| SCHEMBL10309061 | 0.85 | ALDH1A1 (0.74) | ALDH1A1NPSR1KMT2AMEN1MAPK1 | |
| SCHEMBL10309248 | 0.73 | MEN1 (0.65) | ALDH1A1NPSR1KMT2AMEN1MAPK1 | |
| SCHEMBL5075295 | 0.72 | DPP4 (0.71) | ALDH1A1NPSR1KMT2AMEN1MAPK1 | |
| SCHEMBL6876786 | 0.72 | GAA (0.58) | ALDH1A1NPSR1KMT2AMEN1MAPK1 | |
| SCHEMBL5075051 | 0.72 | DPP4 (0.70) | ALDH1A1NPSR1KMT2AMEN1MAPK1 | |
| SCHEMBL555918 | 0.71 | ALDH1A1 (0.81) | ALDH1A1NPSR1KMT2AMEN1MAPK1 | |
| SCHEMBL555919 | 0.71 | ALDH1A1 (0.81) | ALDH1A1NPSR1KMT2AMEN1MAPK1 | |
| SCHEMBL25211939 | 0.70 | GAA (0.57) | ALDH1A1NPSR1MAPK1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178769-A1 | NOVEL COMPOUNDS FOR INHIBITING EEF-2 KINASE ACTIVITY | THE UNIVERSITY OF MEDICINE AND DENTISTRY (US) | 2012-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178769-A1 | NOVEL COMPOUNDS FOR INHIBITING EEF-2 KINASE ACTIVITY | EEF2K, EEF2, EEF1B2 | ALDH1A1 3850/4885NPSR1 4409/4885KMT2A 1478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.