Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | WRN | Q14191 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10310591 | 0.87 | ALDH1A1 (0.35) | ALDH1A1NPSR1KDM4EMEN1KMT2A | |
| SCHEMBL10050026 | 0.82 | SMN1; SMN2 (0.37) | ALDH1A1NPSR1KDM4EMEN1KMT2A | |
| SCHEMBL16203709 | 0.78 | KDM4E (0.31) | ALDH1A1NPSR1KDM4EMEN1KMT2A | |
| SCHEMBL12107536 | 0.78 | CYP1A2 (0.43) | ALDH1A1KDM4EMEN1KMT2AHTT | |
| SCHEMBL13448309 | 0.76 | POLB (0.35) | ALDH1A1NPSR1KDM4EMEN1KMT2A | |
| SCHEMBL12505905 | 0.76 | HTT (0.35) | NPSR1MEN1KMT2AHTTPOLB | |
| SCHEMBL2610530 | 0.76 | POLB (0.36) | ALDH1A1KDM4EHTTPOLBCYP1A2 | |
| SCHEMBL327611 | 0.75 | SMN1; SMN2 (0.35) | ALDH1A1HSD17B10HTTPOLBCYP1A2 | |
| SCHEMBL10037551 | 0.75 | POLB (0.38) | ALDH1A1NPSR1KDM4EMEN1KMT2A | |
| SCHEMBL10037495 | 0.75 | SLC1A2 (0.42) | ALDH1A1NPSR1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889831-B2 | Unit dosage forms of pharmaceutical compositions comprising a polymer-factor VIII polypeptide conjugate | NEKTAR THERAPEUTICS (US) | 2014-11-18 | — | — | US | disclosed |
| US-20120195847-A1 | POLYMER CONJUGATES OF BIPHALIN PEPTIDES | NEKTAR THERAPEUTICS (US) | 2012-08-02 | — | — | US | disclosed |
| US-20120178692-A1 | DOSAGE FORMS OF POLYMER-FACTOR VIII MOIETY CONJUGATES | NEKTAR THERAPEUTICS (US) | 2012-07-12 | — | — | US | disclosed |
| US-20110269713-A1 | BRYOSTATIN ANALOGUES AND METHODS OF MAKING AND USING THEREOF | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2011-11-03 | — | — | US | disclosed |
| US-20110171160-A1 | POLYMER CONJUGATES OF KISS1 PEPTIDES | NEKTAR THERAPEUTICS (US) | 2011-07-14 | — | — | US | disclosed |
| US-20110171161-A1 | POLYMER CONJUGATES OF PROTEGRIN PEPTIDES | NEKTAR THERAPEUTICS (US) | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110171160-A1 | POLYMER CONJUGATES OF KISS1 PEPTIDES | KISS1R, PROKR1, NGLY1 | ALDH1A1 3897/4885NPSR1 27/4885KDM4E 3236/4885 |
| US-20110171161-A1 | POLYMER CONJUGATES OF PROTEGRIN PEPTIDES | PSMG3, PSMB11, PSMC5 | ALDH1A1 4840/4885NPSR1 709/4885KDM4E 4396/4885 |
| US-20120178692-A1 | DOSAGE FORMS OF POLYMER-FACTOR VIII MOIETY CONJUGATES | F8, F9, F13B | ALDH1A1 2188/4885NPSR1 3860/4885KDM4E 2595/4885 |
| US-20110269713-A1 | BRYOSTATIN ANALOGUES AND METHODS OF MAKING AND USING THEREOF | PRKAR2B, PRKAR2A, PRKCH | ALDH1A1 4856/4885NPSR1 2730/4885KDM4E 877/4885 |
| US-20120195847-A1 | POLYMER CONJUGATES OF BIPHALIN PEPTIDES | NGLY1, DNPEP, CIAPIN1 | ALDH1A1 3718/4885NPSR1 214/4885KDM4E 4726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.