Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876578 | 1.00 | CTSV (0.44) | CTSVCTSLCTSBELANECMA1 | |
| SCHEMBL16313103 | 0.93 | CTSV (0.44) | CTSVCTSLCTSBELANECMA1 | |
| SCHEMBL18567784 | 0.92 | CTSV (0.43) | CTSVCTSLCTSBELANECMA1 | |
| SCHEMBL15623646 | 0.92 | CTSV (0.43) | CTSVCTSLCTSBELANECMA1 | |
| SCHEMBL3410890 | 0.90 | CTSV (0.43) | CTSVCTSLCTSBELANECMA1 | |
| SCHEMBL8154517 | 0.90 | CTSV (0.43) | CTSVCTSLCTSBELANECMA1 | |
| SCHEMBL12140547 | 0.89 | CTSB (0.35) | CTSVCTSLCTSBELANECMA1 | |
| SCHEMBL16316248 | 0.89 | CTSB (0.33) | CTSVCTSLCTSBELANECMA1 | |
| SCHEMBL13399542 | 0.89 | CTSB (0.33) | CTSVCTSLCTSBELANECMA1 | |
| SCHEMBL14049403 | 0.88 | CTSV (0.47) | CTSVCTSLCTSBELANECMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459525-B1 | ENANTIO- AND STEREO-SPECIFIC SYNTHESES OF -AMINO- - HYDROXY AMIDES | MERCK SHARP & DOHME (US) | 2017-03-01 | — | — | EP | disclosed |
| US-8680294-B2 | Enantio- and stereo specific synthesis of β-amino-α-hydroxy amides | MERCK SHARP & DOHME CORP. (US) | 2014-03-25 | — | — | US | disclosed |
| US-20120178942-A1 | ENANTIO- AND STEREO-SPECIFIC SYNTHESES OF BETA-AMINO-ALPHA- HYDROXY AMIDES | MERCK SHARP & DOHME LLC | 2012-07-12 | — | — | US | disclosed |
| US-20110286969-A1 | DEUTERATED COMPOUNDS AS HEPATITIS C VIRUS (HCV) INHIBITORS | SCHERING CORPORATION (US) | 2011-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178942-A1 | ENANTIO- AND STEREO-SPECIFIC SYNTHESES OF BETA-AMINO-ALPHA- HYDROXY AMIDES | CYP8B1, DAO, ASPH | CTSV 3493/4885CTSL 2147/4885CTSB 2315/4885 |
| US-20110286969-A1 | DEUTERATED COMPOUNDS AS HEPATITIS C VIRUS (HCV) INHIBITORS | PEPD, PREP, ACE | CTSV 7/4885CTSL 104/4885CTSB 69/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.